DegronMD

Uniprot ID: O95081

Source protein: Arf-GAP domain and FG repeat-containing protein 2

Source gene: AGFG2

Class: DEG_SCF_FBW7_1

Location: 289:294

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 60.3333

COIL: 0.9212

CONS_SCORE: 0.4004

DSS_SCORE: 0.6828

HELIX: 0.0398

FCONS_SCORE: 1.0822

RIG_SCORE: 0.5668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S294R	TCGA-BR-8686	STAD	TCGA	PTPAGS	DEG_SCF_FBW7_1	0.7427
p.S294R	DO48036	STAD	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.7427
p.P291L	TCGA-D9-A4Z6	SKCM	TCGA	PTPAGS	DEG_SCF_FBW7_1	0.7582
p.P291L	DO47485	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.7582
p.S284L	TCGA-EE-A2A6	SKCM	TCGA	PTPAGS	DEG_SCF_FBW7_1	0.1944
p.S284L	DO37591	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.1944
p.G293R	TCGA-GN-A269	SKCM	TCGA	PTPAGS	DEG_SCF_FBW7_1	0.6457
p.G293R	DO37483	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	0.6457
p.G281D	SIDM01090	Colorectal Carcinoma	GDSC	PTPAGS	DEG_SCF_FBW7_1	0.1111
p.G281D	ACH-000943	Colon/Colorectal Cancer	CCLE	PTPAGS	DEG_SCF_FBW7_1	0.1111
p.G281D	RKO	large_intestine	COSMIC	PTPAGS	DEG_SCF_FBW7_1	0.1111
p.Q286L	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PTPAGS	DEG_SCF_FBW7_1	0.25
p.Q286L	TE-15	oesophagus	COSMIC	PTPAGS	DEG_SCF_FBW7_1	0.25
p.P291H	SIDM01608	Endometrial Carcinoma	GDSC	PTPAGS	DEG_SCF_FBW7_1	0.7694
p.P291H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPAGS	DEG_SCF_FBW7_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1L5	Protein FAM117B	DEG_SCF_FBW7_1	11:16	PTPAGS	FBXW7	0.9902	More...
O95081	Arf-GAP domain and FG repeat-containing protein 2	DEG_SCF_FBW7_1	289:294	PTPAGS	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons