DegronMD - O95081(AGFG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A189S	TCGA-44-7669	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7588
p.A189S	DO25262	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7588
p.P182L	TCGA-78-7539	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1389
p.P182L	DO26210	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1389
p.P184L	TCGA-BR-4201	STAD	TCGA	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1944
p.P184L	DO38707	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.1944
p.S294R	TCGA-BR-8686	STAD	TCGA	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7427
p.S294R	DO48036	STAD	ICGC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7427
p.P291L	TCGA-D9-A4Z6	SKCM	TCGA	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7582
p.P291L	DO47485	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7582
p.S284L	TCGA-EE-A2A6	SKCM	TCGA	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1944
p.S284L	DO37591	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1944
p.A190V	TCGA-EE-A3AA	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.5825
p.A190V	DO222632	MELA	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.5825
p.A190V	DO37571	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.5825
p.G293R	TCGA-GN-A269	SKCM	TCGA	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.6457
p.G293R	DO37483	SKCM	ICGC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.6457
p.R203L	DO228952	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0556
p.S194R	DO50897	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.3056
p.P196T	DO229268	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.25
p.V197I	SIDM01123	Prostate Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM01117	Small Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00656	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00041	Gastric Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00846	Cervical Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00633	Breast Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00690	Head and Neck Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00878	Breast Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00391	Plasma Cell Myeloma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00875	Breast Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00844	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00863	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00118	Colorectal Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00720	Mesothelioma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00760	Small Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM01173	Rhabdomyosarcoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.V197I	SIDM00641	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.2222
p.G281D	SIDM01090	Colorectal Carcinoma	GDSC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1111
p.G281D	ACH-000943	Colon/Colorectal Cancer	CCLE	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1111
p.G281D	RKO	large intestine	COSMIC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1111
p.A202T	SIDM01177	B-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.A202T	SIDM00676	Bladder Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.S193L	SIDM00899	Pancreatic Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7667
p.S193L	ACH-000222	Pancreatic Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7667
p.S193L	AsPC-1	pancreas	COSMIC	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7667
p.Q286L	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.25
p.Q286L	TE-15	oesophagus	COSMIC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.25
p.P291H	SIDM01608	Endometrial Carcinoma	GDSC	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7694
p.P291H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPAGS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7694
p.G180S	ACH-000928	Endometrial/Uterine Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.A190T	ACH-001210	Rhabdoid	CCLE	AASTS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.6028

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGFG2

UniProt ID: O95081

Entrez ID: 3268

Protein name: Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGFG2 in