DegronMD

Uniprot ID: O95081

Source protein: Arf-GAP domain and FG repeat-containing protein 2

Source gene: AGFG2

Class: DEG_SPOP_SBC_1

Location: 189:193

E3 ligase: SPOP

DEGRON score: 0.9166

ASA_SCORE: 75

COIL: 0.8982

CONS_SCORE: 0.3623

DSS_SCORE: 0.6582

HELIX: 0.0912

FCONS_SCORE: 0.926

RIG_SCORE: 0.6015

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A189S	TCGA-44-7669	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.7588
p.A189S	DO25262	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.7588
p.P182L	TCGA-78-7539	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.1389
p.P182L	DO26210	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.1389
p.P184L	TCGA-BR-4201	STAD	TCGA	AASTS	DEG_SPOP_SBC_1	0.1944
p.P184L	DO38707	STAD	ICGC	AASTS	DEG_SPOP_SBC_1	0.1944
p.A190V	TCGA-EE-A3AA	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	0.5825
p.A190V	DO222632	MELA	ICGC	AASTS	DEG_SPOP_SBC_1	0.5825
p.A190V	DO37571	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	0.5825
p.R203L	DO228952	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	0.0556
p.S194R	DO50897	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	0.3056
p.P196T	DO229268	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	0.25
p.V197I	SIDM01123	Prostate Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM01117	Small Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00656	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00041	Gastric Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00846	Cervical Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00633	Breast Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00690	Head and Neck Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00878	Breast Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00391	Plasma Cell Myeloma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00875	Breast Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00844	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00863	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00118	Colorectal Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00720	Mesothelioma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00760	Small Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM01173	Rhabdomyosarcoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.V197I	SIDM00641	Burkitt's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.2222
p.A202T	SIDM01177	B-Lymphoblastic Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	0.0833
p.A202T	SIDM00676	Bladder Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.0833
p.S193L	SIDM00899	Pancreatic Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	0.7667
p.S193L	ACH-000222	Pancreatic Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.7667
p.S193L	AsPC-1	pancreas	COSMIC	AASTS	DEG_SPOP_SBC_1	0.7667
p.G180S	ACH-000928	Endometrial/Uterine Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	0.0833
p.A190T	ACH-001210	Rhabdoid	CCLE	AASTS	DEG_SPOP_SBC_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15391	Transcription factor YY2	DEG_SPOP_SBC_1	127:131	AASTS	SPOP	0.8632	More...
O15504	Nucleoporin NUP42	DEG_SPOP_SBC_1	274:278	AASTS	SPOP	0.5936	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	122:126	AASTS	SPOP	0.9939	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	804:808	AASTS	SPOP	0.9913	More...
O95259	Potassium voltage-gated channel subfamily H member 1	DEG_SPOP_SBC_1	802:806	AASTS	SPOP	0.8742	More...
O95721	Synaptosomal-associated protein 29	DEG_SPOP_SBC_1	57:61	AASTS	SPOP	0.8495	More...
P11473	Vitamin D3 receptor	DEG_SPOP_SBC_1	5:9	AASTS	SPOP	0.7318	More...
P18827	Syndecan-1	DEG_SPOP_SBC_1	87:91	AASTS	SPOP	0.9596	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	21:25	AASTS	SPOP	0.9238	More...
Q13049	E3 ubiquitin-protein ligase TRIM32	DEG_SPOP_SBC_1	315:319	AASTS	SPOP	0.925	More...
Q14669	E3 ubiquitin-protein ligase TRIP12	DEG_SPOP_SBC_1	199:203	AASTS	SPOP	0.9879	More...
Q2KHT3	Protein CLEC16A	DEG_SPOP_SBC_1	450:454	AASTS	SPOP	0.6135	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	1155:1159	AASTS	SPOP	0.7759	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SPOP_SBC_1	363:367	AASTS	SPOP	0.8439	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2095:2099	AASTS	SPOP	0.5839	More...
Q9BWF3	RNA-binding protein 4	DEG_SPOP_SBC_1	298:302	AASTS	SPOP	0.9032	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	14:18	AASTS	SPOP	0.9981	More...
Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	DEG_SPOP_SBC_1	616:620	AASTS	SPOP	0.997	More...
Q9UJX2	Cell division cycle protein 23 homolog	DEG_SPOP_SBC_1	2:6	AASTS	SPOP	0.5243	More...
O95081	Arf-GAP domain and FG repeat-containing protein 2	DEG_SPOP_SBC_1	189:193	AASTS	SPOP	0.9166	More...
Q8TC56	Golgi associated RAB2 interactor protein 3	DEG_SPOP_SBC_1	348:352	AASTS	SPOP	0.9521	More...
A6NL46	Putative UPF0607 protein ENSP00000332738	DEG_SPOP_SBC_1	108:112	AASTS	SPOP	0.9403	More...
A8MUA0	Putative UPF0607 protein ENSP00000381514	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.7629	More...
A8MV72	Putative UPF0607 protein ENSP00000382826	DEG_SPOP_SBC_1	79:83	AASTS	SPOP	0.8388	More...
A8MX80	Putative UPF0607 protein ENSP00000383144	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.6735	More...
Q5PR19	Putative UPF0607 protein LOC392364	DEG_SPOP_SBC_1	146:150	AASTS	SPOP	0.6539	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	414:418	AASTS	SPOP	0.97	More...
Q8N9G6	Putative UPF0607 protein FLJ37424	DEG_SPOP_SBC_1	109:113	AASTS	SPOP	0.878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTS

Degron related mutations and impact score

Drug responses associated with AGFG2 mutations

All proteins holding degron of AASTS