DegronMD - Q9HC35(EML4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D10G	TCGA-05-4427	LUAD	TCGA	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10G	TCGA-60-2719	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10G	DO23666	LUAD	ICGC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10G	DO27453	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10G	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10G	ACH-001207	Non-Cancerous	CCLE	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10G	ACH-002157	Lung Cancer	CCLE	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10G	LC-2-ad	lung	COSMIC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.R192H	TCGA-09-0365	OV	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation altering degron motif	0.8244
p.S184Y	TCGA-19-5956	GBM	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation blocking phosphorylation signal	0.5833
p.H182R	TCGA-42-2582	OV	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.0833
p.Q894K	TCGA-AG-3896	READ	TCGA	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation rewiring degron network	0.2222
p.Q894K	TCGA-AG-3896	READ	TCGA	PVSST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1944
p.P199H	TCGA-AM-5821	COAD	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation altering degron motif	0.6583
p.T897A	TCGA-B5-A11E	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation blocking phosphorylation signal	0.75
p.T897A	TCGA-B5-A11E	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	885:889	Mutation blocking phosphorylation signal	0.5556
p.P900L	TCGA-BK-A0C9	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation altering degron motif	0.7582
p.P489S	TCGA-BR-6452	STAD	TCGA	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation altering degron motif	0.5641
p.K207Q	TCGA-BS-A0UV	UCEC	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation substituting flanking lysine	0.2222
p.R192C	TCGA-CD-A4MI	STAD	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation altering degron motif	0.8301
p.D189E	TCGA-CG-4301	STAD	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.2778
p.P900R	TCGA-CN-5355	HNSC	TCGA	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation altering degron motif	0.7512
p.P206Q	TCGA-CV-7421	HNSC	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1389
p.E911K	TCGA-DD-AADJ	LIHC	TCGA	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation rewiring degron network	0.1111
p.S18Y	TCGA-DK-AA71	BLCA	TCGA	AASTS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.8231
p.S18Y	DO219010	BLCA	ICGC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.8231
p.H182Y	TCGA-EY-A1GU	UCEC	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.0833
p.V208F	TCGA-F5-6814	READ	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.0833
p.W185C	TCGA-HE-7129	KIRP	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1667
p.N907S	TCGA-L5-A43J	ESCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation rewiring degron network	0.2222
p.N907S	TCGA-LN-A7HV	ESCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation rewiring degron network	0.2222
p.A877V	TCGA-L5-A8NM	ESCA	TCGA	PVSST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1111
p.D22Y	TCGA-XK-AAIW	PRAD	TCGA	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D22Y	DO51407	PRAD	ICGC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.S483I	TCGA-XM-A8RH	THYM	TCGA	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.25
p.L912I	DO2813	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation rewiring degron network	0.0833
p.E898V	DO1251	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation altering degron motif	0.7693
p.G495D	DO223732	CESC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.2778
p.L477M	DO8730	COAD	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.0833
p.L477M	DO43202	UCEC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.0833
p.L477M	DO41133	UCEC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.0833
p.A499V	DO50354	ESAD	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation blocking phosphorylation signal	0.6111
p.P183L	DO222420	MELA	ICGC	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1111
p.W478L	DO37782	SKCM	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.1111
p.N188S	DO38599	STAD	ICGC	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.25
p.V500A	DO42568	UCEC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.1389
p.R193I	DO41331	UCEC	ICGC	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation altering degron motif	0.8102
p.S502N	SIDM00282	Colorectal Carcinoma	GDSC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation blocking phosphorylation signal	0.5278
p.S502N	ACH-000998	Colon/Colorectal Cancer	CCLE	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation blocking phosphorylation signal	0.5278
p.S502N	CW-2	large intestine	COSMIC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation blocking phosphorylation signal	0.5278
p.V892I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation rewiring degron network	0.1667
p.V892I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PVSST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.25
p.R23H	SIDM00958	Chronic Myelogenous Leukemia	GDSC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.R23H	ACH-000920	Leukemia	CCLE	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.R23H	CML-T1	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.D190G	SIDM00224	Mesothelioma	GDSC	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.3056
p.D190G	ACH-000569	Lung Cancer	CCLE	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.3056
p.D190G	IST-MES1	pleura	COSMIC	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.3056
p.M479I	SIDM01594	Breast Carcinoma	GDSC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	486:493	Mutation rewiring degron network	0.1389
p.I198V	ACH-001375	Pancreatic Cancer	CCLE	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation altering degron motif	0.5965
p.D187H	DJM-1	skin	COSMIC	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.2222
p.D185N	L-363	haematopoietic and lymphoid tissue	COSMIC	SRNKLSKIP	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1667
p.D878E	COR-L23	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1389
p.L912R	SNU-398	liver	COSMIC	PTPPPS	DEG_SCF_FBW7_1	898:903	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EML4

UniProt ID: Q9HC35

Entrez ID: 27436

Protein name: Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EML4 in