DegronMD

Uniprot ID: Q9HC35

Source protein: Echinoderm microtubule-associated protein-like 4

Source gene: EML4

Class: DEG_SCF_FBW7_1

Location: 898:903

E3 ligase: FBXW7

DEGRON score: 0.9906

ASA_SCORE: 84.4833

COIL: 0.9697

CONS_SCORE: 0.5212

DSS_SCORE: 0.7888

HELIX: 0.0157

FCONS_SCORE: 1.0079

RIG_SCORE: 0.5563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q894K	TCGA-AG-3896	READ	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.2222
p.T897A	TCGA-B5-A11E	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.75
p.P900L	TCGA-BK-A0C9	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7582
p.P900R	TCGA-CN-5355	HNSC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7512
p.E911K	TCGA-DD-AADJ	LIHC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.1111
p.N907S	TCGA-L5-A43J	ESCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.2222
p.N907S	TCGA-LN-A7HV	ESCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.2222
p.L912I	DO2813	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.0833
p.E898V	DO1251	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7693
p.V892I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.L912R	SNU-398	liver	COSMIC	PTPPPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95400	CD2 antigen cytoplasmic tail-binding protein 2	DEG_SCF_FBW7_1	242:247	PTPPPS	FBXW7	0.9792	More...
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	426:431	PTPPPS	FBXW7	0.9778	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	2277:2282	PTPPPS	FBXW7	0.9965	More...
Q8NEM7	Transcription factor SPT20 homolog	DEG_SCF_FBW7_1	493:498	PTPPPS	FBXW7	0.9821	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SCF_FBW7_1	898:903	PTPPPS	FBXW7	0.9906	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	808:813	PTPPPS	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons