DegronMD - Q5VZ46(KIAA1614)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S133Y	TCGA-17-Z031	LUAD	TCGA	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.2778
p.G433V	TCGA-92-8064	LUSC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.7532
p.G433V	DO26957	LUSC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.7532
p.S1092N	TCGA-99-8025	LUAD	TCGA	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation rewiring degron network	0.1667
p.S1092N	DO24255	LUAD	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation rewiring degron network	0.1667
p.S813L	TCGA-A5-A0G2	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	TCGA-AX-A2HC	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	TCGA-EO-A3KX	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	DO219774	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	DO41572	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	DO41235	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	SIDM01140	Ovarian Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	ACH-001374	Ovarian Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.S813L	PA-1	ovary	COSMIC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7667
p.E756K	TCGA-A8-A084	BRCA	TCGA	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation altering degron motif	0.591
p.E756K	TCGA-YC-A89H	BLCA	TCGA	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation altering degron motif	0.591
p.E756K	DO51948	BLCA	ICGC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation altering degron motif	0.591
p.E756K	DO1688	BRCA	ICGC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation altering degron motif	0.591
p.A807V	TCGA-AA-3715	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.3056
p.A807V	DO8018	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.3056
p.L801M	TCGA-AB-2833	LAML	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.1389
p.L801M	DO21679	LAML	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.1389
p.R316H	TCGA-AD-6889	COAD	TCGA	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.R316H	DO8463	COAD	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.R316H	DO227709	COCA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.R316H	DO222864	COCA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.R316H	SIDM00335	Endometrial Carcinoma	GDSC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.R316H	SIDM00101	Mesothelioma	GDSC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.T809N	TCGA-AO-A0JD	BRCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7055
p.T809N	DO2860	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.7055
p.S311Y	TCGA-AX-A2HC	UCEC	TCGA	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1389
p.S311Y	DO41572	UCEC	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1389
p.N880D	TCGA-B5-A0K9	UCEC	TCGA	VRHPLLALS	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.25
p.N880D	DO42097	UCEC	ICGC	VRHPLLALS	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.25
p.A126V	TCGA-B5-A11E	UCEC	TCGA	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.0833
p.A126V	DO41644	UCEC	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.0833
p.T128I	TCGA-BG-A222	UCEC	TCGA	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.1389
p.T128I	DO42977	UCEC	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.1389
p.Q145P	TCGA-BK-A0CA	UCEC	TCGA	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.2778
p.Q145P	DO43522	UCEC	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.2778
p.R334Q	TCGA-BR-8369	STAD	TCGA	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.0556
p.R334Q	DO47889	STAD	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.0556
p.P1160H	TCGA-D3-A1QA	SKCM	TCGA	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation altering degron motif	0.6583
p.P1160H	DO47469	SKCM	ICGC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation altering degron motif	0.6583
p.S431F	TCGA-D3-A5GS	SKCM	TCGA	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.7982
p.S431F	DO47706	SKCM	ICGC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.7982
p.G433E	TCGA-DU-6407	LGG	TCGA	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.7199
p.G433E	DO22295	LGG	ICGC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.7199
p.A126S	TCGA-DX-A6YV	SARC	TCGA	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.0833
p.A126S	DO220011	SARC	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.0833
p.T767A	TCGA-E6-A1LX	UCEC	TCGA	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.0833
p.T767A	DO41020	UCEC	ICGC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.0833
p.A1086T	TCGA-EC-A1QX	UCEC	TCGA	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.6028
p.A1086T	DO42592	UCEC	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.6028
p.K815N	TCGA-KK-A7B3	PRAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.2778
p.K815N	DO219309	PRAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.2778
p.T798A	TCGA-Z2-AA3S	SKCM	TCGA	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.0556
p.T798A	DO51302	SKCM	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.0556
p.T750I	DO228471	BRCA	ICGC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	DO229505	LAML	ICGC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	DO225404	LAML	ICGC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00557	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00338	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00216	Colorectal Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00588	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00303	Ovarian Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00586	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00614	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00535	Chondrosarcoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00281	Other Solid Cancers	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00544	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00315	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01005	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00267	Biliary Tract Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00465	Ovarian Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00293	Small Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00457	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00533	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00492	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00556	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01172	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00489	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00294	Small Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00290	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00299	Other Sarcomas	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00247	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01653	Non-Cancerous	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00609	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00574	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00239	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00397	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00207	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00618	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01061	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00655	Other Solid Cancers	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01257	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00579	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00850	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00316	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00604	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00760	Small Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01033	Bladder Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00976	Melanoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00359	Colorectal Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01617	Endometrial Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01577	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01498	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01622	Breast Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01368	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00062	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01776	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01394	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01432	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01469	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00784	Glioma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01494	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01435	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01447	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01321	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01378	Ovarian Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01588	Endometrial Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01451	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM01574	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.T750I	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.2778
p.S430F	DO228935	COCA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.6871
p.S326F	DO222737	COCA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.L152V	DO222842	COCA	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation rewiring degron network	0.0833
p.N1078D	DO229010	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.5821
p.N1078D	DO229013	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.5821
p.N1078D	DO229016	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.5821
p.N1078D	DO229003	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.5821
p.N1078D	DO229005	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.5821
p.L801F	DO229016	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.1389
p.L801F	DO229505	LAML	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.1389
p.L801F	DO228947	LICA	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.1389
p.R1154H	DO234179	ESAD	ICGC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation rewiring degron network	0.2778
p.R316C	DO233151	GACA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.V820A	DO233941	GACA	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.1389
p.P441L	DO229489	LAML	ICGC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00367	Small Cell Lung Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00291	Melanoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00599	Osteosarcoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00587	Biliary Tract Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00276	Biliary Tract Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00566	Oral Cavity Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM01551	Gastric Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00192	Colorectal Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM01412	Oral Cavity Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.P441L	SIDM00159	Biliary Tract Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1389
p.G444V	DO228948	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.0556
p.Q863H	DO228985	LICA	ICGC	VRHPLLALS	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.1667
p.G1158C	DO229018	LICA	ICGC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation altering degron motif	0.76
p.V820L	DO229018	LICA	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.1389
p.K317N	DO23376	LINC	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.3056
p.S430Y	DO229256	LMS	ICGC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.6009
p.P142S	DO230927	LUSC	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation altering degron motif	0.6752
p.P142S	DO224570	LUSC	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation altering degron motif	0.6752
p.R143C	DO222749	MELA	ICGC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation altering degron motif	0.719
p.R143C	SIDM01504	Small Cell Lung Carcinoma	GDSC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation altering degron motif	0.719
p.PR315PC	DO222868	MELA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0
p.P812S	DO229453	SKCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation altering degron motif	0.5641
p.R1154C	DO43218	UCEC	ICGC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation rewiring degron network	0.2778
p.D1156H	SIDM00578	Neuroblastoma	GDSC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation altering degron motif	0.7688
p.D1156H	ACH-000804	Neuroblastoma	CCLE	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation altering degron motif	0.7688
p.L1082H	SIDM00704	Small Cell Lung Carcinoma	GDSC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.7313
p.L1082H	ACH-000639	Lung Cancer	CCLE	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.7313
p.L1082H	NCI-H211	lung	COSMIC	NRSSLYLVA	DEG_APCC_DBOX_1	1078:1086	Mutation altering degron motif	0.7313
p.L1163F	SIDM00217	Colorectal Carcinoma	GDSC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation rewiring degron network	0.2778
p.L1163F	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation rewiring degron network	0.2778
p.L1163F	SNU-1040	large intestine	COSMIC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation rewiring degron network	0.2778
p.R143H	SIDM01608	Endometrial Carcinoma	GDSC	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation altering degron motif	0.7133
p.R143H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LPGAVVAPR	DEG_SIAH_1	135:143	Mutation altering degron motif	0.7133
p.P1155A	SIDM01617	Endometrial Carcinoma	GDSC	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation rewiring degron network	0.3056
p.P1155A	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGMPS	DEG_SCF_TRCP1_1	1156:1161	Mutation rewiring degron network	0.3056
p.C881G	SIDM01450	Gastric Carcinoma	GDSC	VRHPLLALS	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.2222
p.C881G	ACH-000898	Gastric Cancer	CCLE	VRHPLLALS	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.2222
p.S421N	ACH-000943	Colon/Colorectal Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.1111
p.R744K	ACH-000954	Endometrial/Uterine Cancer	CCLE	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.1111
p.G437S	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation rewiring degron network	0.25
p.A751T	ACH-001610	Brain Cancer	CCLE	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation rewiring degron network	0.3056
p.H822Q	ACH-001982	Metastasis	CCLE	PTPPPS	DEG_SCF_FBW7_1	808:813	Mutation rewiring degron network	0.0833
p.D332N	NCI-H2110	lung	COSMIC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1111
p.S434L	PA-1	ovary	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	429:434	Mutation altering degron motif	0.7667
p.S753R	HCC2998	large intestine	COSMIC	PMTPESS	DEG_SCF_FBW7_1	752:758	Mutation altering degron motif	0.7427
p.E326K	EBC-1	lung	COSMIC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.H316Y	SNU-C5	large intestine	COSMIC	VGTPAWT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1614

UniProt ID: Q5VZ46

Entrez ID: 57710

Protein name: Uncharacterized protein KIAA1614

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA1614 in