DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_SIAH_1

Location: 135:143

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9964

ASA_SCORE: 72.4889

COIL: 0.7237

CONS_SCORE: 0.3078

DSS_SCORE: 0.6627

HELIX: 0.0159

FCONS_SCORE: 1.0907

RIG_SCORE: 0.7001

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R143C	DO222749	MELA	ICGC	LPGAVVAPR	DEG_SIAH_1	0.719
p.R143C	SIDM01504	Small Cell Lung Carcinoma	GDSC	LPGAVVAPR	DEG_SIAH_1	0.719
p.R143H	SIDM01608	Endometrial Carcinoma	GDSC	LPGAVVAPR	DEG_SIAH_1	0.7133
p.R143H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LPGAVVAPR	DEG_SIAH_1	0.7133
p.P142S	DO230927	LUSC	ICGC	LPGAVVAPR	DEG_SIAH_1	0.6752
p.P142S	DO224570	LUSC	ICGC	LPGAVVAPR	DEG_SIAH_1	0.6752
p.S133Y	TCGA-17-Z031	LUAD	TCGA	LPGAVVAPR	DEG_SIAH_1	0.2778
p.Q145P	TCGA-BK-A0CA	UCEC	TCGA	LPGAVVAPR	DEG_SIAH_1	0.2778
p.Q145P	DO43522	UCEC	ICGC	LPGAVVAPR	DEG_SIAH_1	0.2778
p.T128I	TCGA-BG-A222	UCEC	TCGA	LPGAVVAPR	DEG_SIAH_1	0.1389
p.T128I	DO42977	UCEC	ICGC	LPGAVVAPR	DEG_SIAH_1	0.1389
p.A126V	TCGA-B5-A11E	UCEC	TCGA	LPGAVVAPR	DEG_SIAH_1	0.0833
p.A126V	DO41644	UCEC	ICGC	LPGAVVAPR	DEG_SIAH_1	0.0833
p.A126S	TCGA-DX-A6YV	SARC	TCGA	LPGAVVAPR	DEG_SIAH_1	0.0833
p.A126S	DO220011	SARC	ICGC	LPGAVVAPR	DEG_SIAH_1	0.0833
p.L152V	DO222842	COCA	ICGC	LPGAVVAPR	DEG_SIAH_1	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SIAH_1	135:143	LPGAVVAPR	SIAH1,SIAH2,SIAH3	0.9964	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons