DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_SCF_FBW7_1

Location: 318:324

E3 ligase: FBXW7

DEGRON score: 0.9536

ASA_SCORE: 73.1857

COIL: 0.8703

CONS_SCORE: 0.2924

DSS_SCORE: 0.5816

HELIX: 0.0226

FCONS_SCORE: 0.9784

RIG_SCORE: 0.6863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R316H	TCGA-AD-6889	COAD	TCGA	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.R316H	DO8463	COAD	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.R316H	DO227709	COCA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.R316H	DO222864	COCA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.R316H	SIDM00335	Endometrial Carcinoma	GDSC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.R316H	SIDM00101	Mesothelioma	GDSC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.S311Y	TCGA-AX-A2HC	UCEC	TCGA	VGTPAWT	DEG_SCF_FBW7_1	0.1389
p.S311Y	DO41572	UCEC	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.1389
p.R334Q	TCGA-BR-8369	STAD	TCGA	VGTPAWT	DEG_SCF_FBW7_1	0.0556
p.R334Q	DO47889	STAD	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.0556
p.S326F	DO222737	COCA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.R316C	DO233151	GACA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.K317N	DO23376	LINC	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0.3056
p.PR315PC	DO222868	MELA	ICGC	VGTPAWT	DEG_SCF_FBW7_1	0
p.D332N	NCI-H2110	lung	COSMIC	VGTPAWT	DEG_SCF_FBW7_1	0.1111
p.E326K	EBC-1	lung	COSMIC	VGTPAWT	DEG_SCF_FBW7_1	0.2778
p.H316Y	SNU-C5	large_intestine	COSMIC	VGTPAWT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	318:324	VGTPAWT	FBXW7	0.9536	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons