DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_APCC_DBOX_1

Location: 1078:1086

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9982

ASA_SCORE: 79.5778

COIL: 0.8034

CONS_SCORE: 0.7291

DSS_SCORE: 0.4722

HELIX: 0.1286

FCONS_SCORE: 1.3806

RIG_SCORE: 0.6719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1092N	TCGA-99-8025	LUAD	TCGA	NRSSLYLVA	DEG_APCC_DBOX_1	0.1667
p.S1092N	DO24255	LUAD	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	0.1667
p.A1086T	TCGA-EC-A1QX	UCEC	TCGA	NRSSLYLVA	DEG_APCC_DBOX_1	0.6028
p.A1086T	DO42592	UCEC	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	0.6028
p.N1078D	DO229010	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	0.5821
p.N1078D	DO229013	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	0.5821
p.N1078D	DO229016	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	0.5821
p.N1078D	DO229003	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	0.5821
p.N1078D	DO229005	COCA	ICGC	NRSSLYLVA	DEG_APCC_DBOX_1	0.5821
p.L1082H	SIDM00704	Small Cell Lung Carcinoma	GDSC	NRSSLYLVA	DEG_APCC_DBOX_1	0.7313
p.L1082H	ACH-000639	Lung Cancer	CCLE	NRSSLYLVA	DEG_APCC_DBOX_1	0.7313
p.L1082H	NCI-H211	lung	COSMIC	NRSSLYLVA	DEG_APCC_DBOX_1	0.7313

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ46	Uncharacterized protein KIAA1614	DEG_APCC_DBOX_1	1078:1086	NRSSLYLVA	APC,CDC20,FZR1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons