DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_APCC_DBOX_1

Location: 869:877

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8593

ASA_SCORE: 98.6444

COIL: 0.8651

CONS_SCORE: 0.5325

DSS_SCORE: 0.6155

HELIX: 0.0793

FCONS_SCORE: 1.1604

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N880D	TCGA-B5-A0K9	UCEC	TCGA	VRHPLLALS	DEG_APCC_DBOX_1	0.25
p.N880D	DO42097	UCEC	ICGC	VRHPLLALS	DEG_APCC_DBOX_1	0.25
p.Q863H	DO228985	LICA	ICGC	VRHPLLALS	DEG_APCC_DBOX_1	0.1667
p.C881G	SIDM01450	Gastric Carcinoma	GDSC	VRHPLLALS	DEG_APCC_DBOX_1	0.2222
p.C881G	ACH-000898	Gastric Cancer	CCLE	VRHPLLALS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ46	Uncharacterized protein KIAA1614	DEG_APCC_DBOX_1	869:877	VRHPLLALS	APC,CDC20,FZR1	0.8593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons