DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_SCF_FBW7_1

Location: 752:758

E3 ligase: FBXW7

DEGRON score: 0.9708

ASA_SCORE: 95.3714

COIL: 0.955

CONS_SCORE: 0.4164

DSS_SCORE: 0.722

HELIX: 0.0206

FCONS_SCORE: 1.3098

RIG_SCORE: 0.6024

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E756K	TCGA-A8-A084	BRCA	TCGA	PMTPESS	DEG_SCF_FBW7_1	0.591
p.E756K	TCGA-YC-A89H	BLCA	TCGA	PMTPESS	DEG_SCF_FBW7_1	0.591
p.E756K	DO51948	BLCA	ICGC	PMTPESS	DEG_SCF_FBW7_1	0.591
p.E756K	DO1688	BRCA	ICGC	PMTPESS	DEG_SCF_FBW7_1	0.591
p.T767A	TCGA-E6-A1LX	UCEC	TCGA	PMTPESS	DEG_SCF_FBW7_1	0.0833
p.T767A	DO41020	UCEC	ICGC	PMTPESS	DEG_SCF_FBW7_1	0.0833
p.T750I	DO228471	BRCA	ICGC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	DO229505	LAML	ICGC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	DO225404	LAML	ICGC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00557	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00338	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00216	Colorectal Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00588	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00303	Ovarian Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00586	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00614	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00535	Chondrosarcoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00281	Other Solid Cancers	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00544	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00315	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01005	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00267	Biliary Tract Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00465	Ovarian Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00293	Small Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00457	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00533	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00492	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00556	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01172	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00489	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00294	Small Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00290	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00299	Other Sarcomas	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00247	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01653	Non-Cancerous	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00609	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00574	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00239	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00397	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00207	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00618	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01061	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00655	Other Solid Cancers	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01257	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00579	Neuroblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00850	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00316	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00604	Oral Cavity Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00760	Small Cell Lung Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01033	Bladder Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00976	Melanoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00359	Colorectal Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01617	Endometrial Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01577	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01498	Acute Myeloid Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01622	Breast Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01368	Gastric Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00062	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01776	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01394	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01432	Kidney Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01469	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00784	Glioma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01494	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01435	Hepatocellular Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01447	Glioblastoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01321	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01378	Ovarian Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01588	Endometrial Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01451	Pancreatic Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM01574	Plasma Cell Myeloma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.T750I	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PMTPESS	DEG_SCF_FBW7_1	0.2778
p.R744K	ACH-000954	Endometrial/Uterine Cancer	CCLE	PMTPESS	DEG_SCF_FBW7_1	0.1111
p.A751T	ACH-001610	Brain Cancer	CCLE	PMTPESS	DEG_SCF_FBW7_1	0.3056
p.S753R	HCC2998	large_intestine	COSMIC	PMTPESS	DEG_SCF_FBW7_1	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMTPESS

Degron related mutations and impact score

Drug responses associated with KIAA1614 mutations

All proteins holding degron of PMTPESS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	752:758	PMTPESS	FBXW7	0.9708	More...