DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_SCF_TRCP1_1

Location: 1156:1161

E3 ligase: BTRC

DEGRON score: 0.8078

ASA_SCORE: 66.6

COIL: 0.9143

CONS_SCORE: 0.5858

DSS_SCORE: 0.6519

HELIX: 0.0132

FCONS_SCORE: 1.2291

RIG_SCORE: 0.5821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1160H	TCGA-D3-A1QA	SKCM	TCGA	DSGMPS	DEG_SCF_TRCP1_1	0.6583
p.P1160H	DO47469	SKCM	ICGC	DSGMPS	DEG_SCF_TRCP1_1	0.6583
p.R1154H	DO234179	ESAD	ICGC	DSGMPS	DEG_SCF_TRCP1_1	0.2778
p.G1158C	DO229018	LICA	ICGC	DSGMPS	DEG_SCF_TRCP1_1	0.76
p.R1154C	DO43218	UCEC	ICGC	DSGMPS	DEG_SCF_TRCP1_1	0.2778
p.D1156H	SIDM00578	Neuroblastoma	GDSC	DSGMPS	DEG_SCF_TRCP1_1	0.7688
p.D1156H	ACH-000804	Neuroblastoma	CCLE	DSGMPS	DEG_SCF_TRCP1_1	0.7688
p.L1163F	SIDM00217	Colorectal Carcinoma	GDSC	DSGMPS	DEG_SCF_TRCP1_1	0.2778
p.L1163F	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGMPS	DEG_SCF_TRCP1_1	0.2778
p.L1163F	SNU-1040	large_intestine	COSMIC	DSGMPS	DEG_SCF_TRCP1_1	0.2778
p.P1155A	SIDM01617	Endometrial Carcinoma	GDSC	DSGMPS	DEG_SCF_TRCP1_1	0.3056
p.P1155A	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGMPS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_TRCP1_1	1156:1161	DSGMPS	BTRC	0.8078	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons