DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_SCF_FBW7_1

Location: 808:813

E3 ligase: FBXW7

DEGRON score: 0.9846

ASA_SCORE: 91.05

COIL: 0.975

CONS_SCORE: 0.5579

DSS_SCORE: 0.6772

HELIX: 0.0118

FCONS_SCORE: 1.2283

RIG_SCORE: 0.5776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S813L	TCGA-A5-A0G2	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	TCGA-AX-A2HC	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	TCGA-EO-A3KX	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	DO219774	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	DO41572	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	DO41235	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	SIDM01140	Ovarian Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	ACH-001374	Ovarian Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.S813L	PA-1	ovary	COSMIC	PTPPPS	DEG_SCF_FBW7_1	0.7667
p.A807V	TCGA-AA-3715	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.A807V	DO8018	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.L801M	TCGA-AB-2833	LAML	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.1389
p.L801M	DO21679	LAML	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1389
p.T809N	TCGA-AO-A0JD	BRCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7055
p.T809N	DO2860	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7055
p.K815N	TCGA-KK-A7B3	PRAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.2778
p.K815N	DO219309	PRAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.2778
p.T798A	TCGA-Z2-AA3S	SKCM	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.0556
p.T798A	DO51302	SKCM	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.0556
p.L801F	DO229016	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1389
p.L801F	DO229505	LAML	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1389
p.L801F	DO228947	LICA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1389
p.V820A	DO233941	GACA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1389
p.V820L	DO229018	LICA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1389
p.P812S	DO229453	SKCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.5641
p.H822Q	ACH-001982	Metastasis	CCLE	PTPPPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95400	CD2 antigen cytoplasmic tail-binding protein 2	DEG_SCF_FBW7_1	242:247	PTPPPS	FBXW7	0.9792	More...
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	426:431	PTPPPS	FBXW7	0.9778	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	2277:2282	PTPPPS	FBXW7	0.9965	More...
Q8NEM7	Transcription factor SPT20 homolog	DEG_SCF_FBW7_1	493:498	PTPPPS	FBXW7	0.9821	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SCF_FBW7_1	898:903	PTPPPS	FBXW7	0.9906	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	808:813	PTPPPS	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons