DegronMD

Uniprot ID: Q8NEM7

Source protein: Transcription factor SPT20 homolog

Source gene: SUPT20H

Class: DEG_SCF_FBW7_1

Location: 493:498

E3 ligase: FBXW7

DEGRON score: 0.9821

ASA_SCORE: 98.2333

COIL: 0.9797

CONS_SCORE: 0.4925

DSS_SCORE: 0.7178

HELIX: 0.0082

FCONS_SCORE: 1.0726

RIG_SCORE: 0.5202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P497S	TCGA-A6-2686	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.5641
p.P497S	TCGA-AP-A054	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.5641
p.P497S	TCGA-F1-6177	STAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.5641
p.P498S	DO7828	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.6752
p.P498S	DO233737	GACA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.6752
p.P498S	DO38727	STAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.6752
p.P498S	DO42256	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.6752
p.S488G	DO23296	LINC	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1944
p.S488R	DO45221	LIRI	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1944
p.S503R	SIDM00789	Colorectal Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.6389
p.S503R	ACH-000997	Colon/Colorectal Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	0.6389
p.S503R	ACH-001061	Colon/Colorectal Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	0.6389
p.S503R	HCT-15	large_intestine	COSMIC	PTPPPS	DEG_SCF_FBW7_1	0.6389
p.K500T	SIDM01451	Pancreatic Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.2778
p.K500T	ACH-000933	Pancreatic Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	0.2778
p.S504R	HCT-15	large_intestine	COSMIC	PTPPPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95400	CD2 antigen cytoplasmic tail-binding protein 2	DEG_SCF_FBW7_1	242:247	PTPPPS	FBXW7	0.9792	More...
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	426:431	PTPPPS	FBXW7	0.9778	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	2277:2282	PTPPPS	FBXW7	0.9965	More...
Q8NEM7	Transcription factor SPT20 homolog	DEG_SCF_FBW7_1	493:498	PTPPPS	FBXW7	0.9821	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SCF_FBW7_1	898:903	PTPPPS	FBXW7	0.9906	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	808:813	PTPPPS	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons