DegronMD - Q16204(CCDC6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S359F	TCGA-06-5416	GBM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation altering degron motif	0.7982
p.S359F	DO10880	GBM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation altering degron motif	0.7982
p.S359Y	TCGA-19-5956	GBM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation altering degron motif	0.712
p.S359Y	DO13863	GBM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation altering degron motif	0.712
p.S351Y	TCGA-34-2600	LUSC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation blocking phosphorylation signal	0.6944
p.S351Y	DO27081	LUSC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation blocking phosphorylation signal	0.6944
p.N394Y	TCGA-67-3771	LUAD	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.0556
p.N394Y	DO25797	LUAD	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.0556
p.P347H	TCGA-A5-A0G2	UCEC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1389
p.P347H	DO41235	UCEC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1389
p.P358H	TCGA-A5-A1OF	UCEC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation altering degron motif	0.7694
p.P358H	DO42568	UCEC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation altering degron motif	0.7694
p.F423I	TCGA-AA-3947	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.25
p.F423I	DO8192	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.25
p.T383A	TCGA-AJ-A3EK	UCEC	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.7139
p.T383A	DO41584	UCEC	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.7139
p.G389E	TCGA-BR-8680	STAD	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.1944
p.G389E	DO47769	STAD	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.1944
p.R348H	TCGA-C5-A2LY	CESC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1667
p.R348H	DO6314	CESC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1667
p.P368H	TCGA-D3-A1Q6	SKCM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1389
p.P368H	TCGA-D3-A1Q6	SKCM	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.0833
p.P368H	DO228971	LICA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1389
p.P368H	DO228971	LICA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.0833
p.P368H	DO37450	SKCM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1389
p.P368H	DO37450	SKCM	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.0833
p.P382Q	TCGA-EE-A3AD	SKCM	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.5924
p.P382Q	DO37707	SKCM	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.5924
p.R387I	TCGA-EO-A3KX	UCEC	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.25
p.R387I	DO219774	UCEC	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.25
p.G369C	TCGA-ER-A19F	SKCM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1111
p.G369C	TCGA-ER-A19F	SKCM	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.1111
p.G369C	DO37679	SKCM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1111
p.G369C	DO37679	SKCM	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.1111
p.R425W	TCGA-EW-A1J3	BRCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.3056
p.R425W	DO3049	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.3056
p.T380M	TCGA-G4-6627	COAD	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.8534
p.T380M	DO9098	COAD	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.8534
p.T427M	TCGA-IN-A6RP	STAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation altering degron motif	0.8534
p.T427M	DO51741	STAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation altering degron motif	0.8534
p.F423L	TCGA-LN-A49W	ESCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.25
p.P365S	TCGA-QH-A6CY	LGG	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.2222
p.P365S	DO50172	LGG	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.2222
p.P437T	DO227802	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.1667
p.R346I	DO222884	COCA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.1111
p.T376M	DO233946	GACA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation blocking phosphorylation signal	0.75
p.L385M	DO229015	LICA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation rewiring degron network	0.3056
p.P358T	DO229025	LICA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation altering degron motif	0.7031
p.P353T	DO229026	LICA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	354:361	Mutation rewiring degron network	0.3056
p.P440T	DO229026	LICA	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.0833
p.P381Q	DO229034	LICA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.7035
p.P420L	DO220851	MELA	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.1667
p.P430L	DO220907	MELA	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation altering degron motif	0.6471
p.P381L	DO227759	PBCA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	377:384	Mutation altering degron motif	0.7582
p.R425P	DO218849	SKCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	426:431	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC6

UniProt ID: Q16204

Entrez ID: 8030

Protein name: Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC6 in