DegronMD

Uniprot ID: Q16204

Source protein: Coiled-coil domain-containing protein 6

Source gene: CCDC6

Class: DEG_SCF_FBW7_1

Location: 377:384

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 80.55

COIL: 0.9465

CONS_SCORE: 0.3841

DSS_SCORE: 0.4135

HELIX: 0.0228

FCONS_SCORE: 0.9862

RIG_SCORE: 0.7022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N394Y	TCGA-67-3771	LUAD	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.0556
p.N394Y	DO25797	LUAD	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.0556
p.T383A	TCGA-AJ-A3EK	UCEC	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.7139
p.T383A	DO41584	UCEC	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.7139
p.G389E	TCGA-BR-8680	STAD	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.1944
p.G389E	DO47769	STAD	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.1944
p.P368H	TCGA-D3-A1Q6	SKCM	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.0833
p.P368H	DO228971	LICA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.0833
p.P368H	DO37450	SKCM	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.0833
p.P382Q	TCGA-EE-A3AD	SKCM	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.5924
p.P382Q	DO37707	SKCM	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.5924
p.R387I	TCGA-EO-A3KX	UCEC	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.25
p.R387I	DO219774	UCEC	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.25
p.G369C	TCGA-ER-A19F	SKCM	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.1111
p.G369C	DO37679	SKCM	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.1111
p.T380M	TCGA-G4-6627	COAD	TCGA	VGFTPPTS	DEG_SCF_FBW7_1	0.8534
p.T380M	DO9098	COAD	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.8534
p.T376M	DO233946	GACA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.75
p.L385M	DO229015	LICA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.3056
p.P381Q	DO229034	LICA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.7035
p.P381L	DO227759	PBCA	ICGC	VGFTPPTS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	377:384	VGFTPPTS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons