DegronMD

Uniprot ID: Q16204

Source protein: Coiled-coil domain-containing protein 6

Source gene: CCDC6

Class: DEG_SCF_FBW7_1

Location: 426:431

E3 ligase: FBXW7

DEGRON score: 0.9778

ASA_SCORE: 91

COIL: 0.9857

CONS_SCORE: 0.3675

DSS_SCORE: 0.9007

HELIX: 0.0062

FCONS_SCORE: 1.0504

RIG_SCORE: 0.4239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F423I	TCGA-AA-3947	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.25
p.F423I	DO8192	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.25
p.R425W	TCGA-EW-A1J3	BRCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.R425W	DO3049	BRCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.T427M	TCGA-IN-A6RP	STAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.8534
p.T427M	DO51741	STAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.8534
p.F423L	TCGA-LN-A49W	ESCA	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.25
p.P437T	DO227802	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P440T	DO229026	LICA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.0833
p.P420L	DO220851	MELA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P430L	DO220907	MELA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.6471
p.R425P	DO218849	SKCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95400	CD2 antigen cytoplasmic tail-binding protein 2	DEG_SCF_FBW7_1	242:247	PTPPPS	FBXW7	0.9792	More...
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	426:431	PTPPPS	FBXW7	0.9778	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	2277:2282	PTPPPS	FBXW7	0.9965	More...
Q8NEM7	Transcription factor SPT20 homolog	DEG_SCF_FBW7_1	493:498	PTPPPS	FBXW7	0.9821	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SCF_FBW7_1	898:903	PTPPPS	FBXW7	0.9906	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	808:813	PTPPPS	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons