DegronMD

Uniprot ID: O95400

Source protein: CD2 antigen cytoplasmic tail-binding protein 2

Source gene: CD2BP2

Class: DEG_SCF_FBW7_1

Location: 242:247

E3 ligase: FBXW7

DEGRON score: 0.9792

ASA_SCORE: 77.8667

COIL: 0.9215

CONS_SCORE: 0.2545

DSS_SCORE: 0.7088

HELIX: 0.061

FCONS_SCORE: 0.777

RIG_SCORE: 0.5904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S247P	TCGA-BR-6452	STAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7863
p.S247P	DO38404	STAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7863
p.P242L	TCGA-MP-A4TK	LUAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.6471
p.P242L	DO45384	LUAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.6471
p.A256V	DO233127	GACA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.0833
p.A256E	DO229035	LICA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.0833
p.P239L	DO232761	PBCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.25
p.P246S	SIDM01387	Small Cell Lung Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.5641
p.P246S	ACH-000921	Lung Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95400	CD2 antigen cytoplasmic tail-binding protein 2	DEG_SCF_FBW7_1	242:247	PTPPPS	FBXW7	0.9792	More...
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	426:431	PTPPPS	FBXW7	0.9778	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	2277:2282	PTPPPS	FBXW7	0.9965	More...
Q8NEM7	Transcription factor SPT20 homolog	DEG_SCF_FBW7_1	493:498	PTPPPS	FBXW7	0.9821	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SCF_FBW7_1	898:903	PTPPPS	FBXW7	0.9906	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	808:813	PTPPPS	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons