DegronMD - Q8NEM7(SUPT20H)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P497S	TCGA-A6-2686	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.5641
p.P497S	TCGA-AP-A054	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.5641
p.P497S	TCGA-F1-6177	STAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.5641
p.S519Y	TCGA-AG-A002	READ	TCGA	PASSS	DEG_SPOP_SBC_1	525:529	Mutation blocking phosphorylation signal	0.6111
p.S519F	TCGA-AP-A0LM	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	525:529	Mutation blocking phosphorylation signal	0.6111
p.S519C	TCGA-MZ-A7D7	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	525:529	Mutation blocking phosphorylation signal	0.6111
p.M517V	TCGA-WA-A7GZ	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.Q515E	DO6254	CESC	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0556
p.P498S	DO7828	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.6752
p.P498S	DO233737	GACA	ICGC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.6752
p.P498S	DO38727	STAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.6752
p.P498S	DO42256	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.6752
p.T533M	DO230336	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2222
p.S525L	DO234269	ESAD	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7667
p.M518V	DO219094	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1389
p.S520C	DO52093	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1944
p.S538P	DO49773	KIRP	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0833
p.T539N	DO229026	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0556
p.T534A	DO44790	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1944
p.S488G	DO23296	LINC	ICGC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1944
p.S488R	DO45221	LIRI	ICGC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1944
p.S520F	DO43306	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1944
p.S503R	SIDM00789	Colorectal Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation blocking phosphorylation signal	0.6389
p.S503R	ACH-000997	Colon/Colorectal Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation blocking phosphorylation signal	0.6389
p.S503R	ACH-001061	Colon/Colorectal Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation blocking phosphorylation signal	0.6389
p.S503R	HCT-15	large intestine	COSMIC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation blocking phosphorylation signal	0.6389
p.K500T	SIDM01451	Pancreatic Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2778
p.K500T	ACH-000933	Pancreatic Cancer	CCLE	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2778
p.S504R	HCT-15	large intestine	COSMIC	PTPPPS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1667

Kaplan plot for SUPT20H in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUPT20H

UniProt ID: Q8NEM7

Entrez ID: 55578

Protein name: Transcription factor SPT20 homolog (p38-interacting protein) (p38IP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUPT20H in