DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SCF_FBW7_1

Location: 2277:2282

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 97.9167

COIL: 0.9783

CONS_SCORE: 0.4758

DSS_SCORE: 0.9444

HELIX: 0.0075

FCONS_SCORE: 1.2232

RIG_SCORE: 0.4213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2273T	TCGA-44-7670	LUAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.2222
p.P2273T	DO23555	LUAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.2222
p.P2283Q	TCGA-69-7974	LUAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.P2283Q	DO23850	LUAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.P2277H	TCGA-AA-3833	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.7694
p.P2277H	DO9796	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7694
p.P2277S	TCGA-AA-3864	COAD	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.6752
p.P2277S	DO8490	COAD	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.6752
p.R2276M	TCGA-AP-A059	UCEC	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.R2276M	DO41361	UCEC	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.3056
p.P2288L	TCGA-EE-A2GJ	SKCM	TCGA	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P2288L	DO37746	SKCM	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.G2285R	DO222990	BTCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.25
p.G2285R	DO229013	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.25
p.G2285R	DO229016	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.25
p.G2285R	DO229005	COCA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.25
p.P2279L	DO222702	MELA	ICGC	PTPPPS	DEG_SCF_FBW7_1	0.7582
p.P2271R	SIDM00985	Burkitt's Lymphoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P2271R	SIDM00258	Neuroblastoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P2271R	SIDM00127	Oral Cavity Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P2271R	SIDM01055	Glioblastoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P2271R	SIDM00983	Bladder Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.P2271R	SIDM00182	Head and Neck Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.1667
p.S2282F	SIDM00650	Small Cell Lung Carcinoma	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.7982
p.S2282F	SIDM01681	Non-Cancerous	GDSC	PTPPPS	DEG_SCF_FBW7_1	0.7982
p.P2292S	ACH-001275	Sarcoma	CCLE	PTPPPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95400	CD2 antigen cytoplasmic tail-binding protein 2	DEG_SCF_FBW7_1	242:247	PTPPPS	FBXW7	0.9792	More...
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	426:431	PTPPPS	FBXW7	0.9778	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	2277:2282	PTPPPS	FBXW7	0.9965	More...
Q8NEM7	Transcription factor SPT20 homolog	DEG_SCF_FBW7_1	493:498	PTPPPS	FBXW7	0.9821	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SCF_FBW7_1	898:903	PTPPPS	FBXW7	0.9906	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_SCF_FBW7_1	808:813	PTPPPS	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPPPS

Degron related mutations and impact score

Drug responses associated with RP1L1 mutations

All proteins holding degron of PTPPPS