DegronMD

Uniprot ID: Q16204

Source protein: Coiled-coil domain-containing protein 6

Source gene: CCDC6

Class: DEG_SCF_FBW7_1

Location: 354:361

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 98.125

COIL: 0.9723

CONS_SCORE: 0.3878

DSS_SCORE: 0.6013

HELIX: 0.0102

FCONS_SCORE: 0.8708

RIG_SCORE: 0.5983

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S359F	TCGA-06-5416	GBM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.7982
p.S359F	DO10880	GBM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.7982
p.S359Y	TCGA-19-5956	GBM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.712
p.S359Y	DO13863	GBM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.712
p.S351Y	TCGA-34-2600	LUSC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.6944
p.S351Y	DO27081	LUSC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.6944
p.P347H	TCGA-A5-A0G2	UCEC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.1389
p.P347H	DO41235	UCEC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.1389
p.P358H	TCGA-A5-A1OF	UCEC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.7694
p.P358H	DO42568	UCEC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.7694
p.R348H	TCGA-C5-A2LY	CESC	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.1667
p.R348H	DO6314	CESC	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.1667
p.P368H	TCGA-D3-A1Q6	SKCM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.1389
p.P368H	DO228971	LICA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.1389
p.P368H	DO37450	SKCM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.1389
p.G369C	TCGA-ER-A19F	SKCM	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.1111
p.G369C	DO37679	SKCM	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.1111
p.P365S	TCGA-QH-A6CY	LGG	TCGA	IPYTPSPS	DEG_SCF_FBW7_1	0.2222
p.P365S	DO50172	LGG	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.2222
p.R346I	DO222884	COCA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.1111
p.P358T	DO229025	LICA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.7031
p.P353T	DO229026	LICA	ICGC	IPYTPSPS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16204	Coiled-coil domain-containing protein 6	DEG_SCF_FBW7_1	354:361	IPYTPSPS	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons