DegronMD

Uniprot ID: Q5VZ46

Source protein: Uncharacterized protein KIAA1614

Source gene: KIAA1614

Class: DEG_Kelch_Keap1_1

Location: 429:434

E3 ligase: KEAP1

DEGRON score: 0.9956

ASA_SCORE: 87.5833

COIL: 0.9405

CONS_SCORE: 0.836

DSS_SCORE: 0.8287

HELIX: 0.0423

FCONS_SCORE: 1.4153

RIG_SCORE: 0.4467

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G433V	TCGA-92-8064	LUSC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.7532
p.G433V	DO26957	LUSC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.7532
p.S431F	TCGA-D3-A5GS	SKCM	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.7982
p.S431F	DO47706	SKCM	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.7982
p.G433E	TCGA-DU-6407	LGG	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.7199
p.G433E	DO22295	LGG	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.7199
p.S430F	DO228935	COCA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.6871
p.P441L	DO229489	LAML	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00367	Small Cell Lung Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00291	Melanoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00599	Osteosarcoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00587	Biliary Tract Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00276	Biliary Tract Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00566	Oral Cavity Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM01551	Gastric Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00192	Colorectal Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM01412	Oral Cavity Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P441L	SIDM00159	Biliary Tract Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.G444V	DO228948	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.0556
p.S430Y	DO229256	LMS	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.6009
p.S421N	ACH-000943	Colon/Colorectal Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.1111
p.G437S	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.25
p.S434L	PA-1	ovary	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_Kelch_Keap1_1	500:505	DSSSGE	KEAP1	0.9162	More...
Q03111	Protein ENL	DEG_Kelch_Keap1_1	418:423	DSSSGE	KEAP1	0.9967	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_Kelch_Keap1_1	429:434	DSSSGE	KEAP1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSSSGE

Degron related mutations and impact score

Drug responses associated with KIAA1614 mutations

All proteins holding degron of DSSSGE