DegronMD

Uniprot ID: O60673

Source protein: DNA polymerase zeta catalytic subunit

Source gene: REV3L

Class: DEG_Kelch_Keap1_1

Location: 500:505

E3 ligase: KEAP1

DEGRON score: 0.9162

ASA_SCORE: 80.9

COIL: 0.844

CONS_SCORE: 0.2695

DSS_SCORE: 0.6527

HELIX: 0.1275

FCONS_SCORE: 0.9154

RIG_SCORE: 0.5886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S513G	TCGA-44-7660	LUAD	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.1111
p.S513G	DO23834	LUAD	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.1111
p.S510I	TCGA-AP-A0LM	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.1944
p.S510I	DO43306	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.1944
p.E508K	TCGA-AX-A1CE	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.25
p.E508K	DO42280	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.25
p.D498Y	TCGA-B5-A0JY	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.2778
p.D498Y	DO43041	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.2778
p.D500N	TCGA-B5-A3FA	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.5821
p.D500N	DO52402	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.5821
p.D500N	SIDM00150	Colorectal Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.5821
p.D500N	ACH-000969	Colon/Colorectal Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.5821
p.D500N	KM12	large_intestine	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	0.5821
p.N512K	DO228976	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.1389
p.D500E	DO229037	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.6758
p.S501L	SIDM01220	Glioma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.6556
p.S501L	ACH-000760	Brain Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.6556
p.S501L	ACH-002269	Brain Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.6556
p.S501L	LNZTA3WT4	central_nervous_system	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	0.6556
p.T496A	SIDM01318	Hepatocellular Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	0.2222
p.K496R	KATOIII	stomach	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_Kelch_Keap1_1	500:505	DSSSGE	KEAP1	0.9162	More...
Q03111	Protein ENL	DEG_Kelch_Keap1_1	418:423	DSSSGE	KEAP1	0.9967	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_Kelch_Keap1_1	429:434	DSSSGE	KEAP1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons