DegronMD

Uniprot ID: Q03111

Source protein: Protein ENL

Source gene: MLLT1

Class: DEG_Kelch_Keap1_1

Location: 418:423

E3 ligase: KEAP1

DEGRON score: 0.9967

ASA_SCORE: 84.6667

COIL: 0.8333

CONS_SCORE: 0.5036

DSS_SCORE: 0.8614

HELIX: 0.1527

FCONS_SCORE: 1.0321

RIG_SCORE: 0.5327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A425V	TCGA-AP-A059	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	0.2778
p.A425V	DO41361	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.2778
p.E423K	DO234392	ESAD	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.7022
p.E423K	ACH-000774	Lung Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.7022
p.G432W	DO48320	ESCA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.0833
p.T429N	DO229045	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.1667
p.P431Q	DO229008	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.1111
p.S421L	DO229259	THCA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	0.8778
p.P431L	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.1111
p.D418N	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_Kelch_Keap1_1	500:505	DSSSGE	KEAP1	0.9162	More...
Q03111	Protein ENL	DEG_Kelch_Keap1_1	418:423	DSSSGE	KEAP1	0.9967	More...
Q5VZ46	Uncharacterized protein KIAA1614	DEG_Kelch_Keap1_1	429:434	DSSSGE	KEAP1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons