DegronMD - O60673(REV3L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H641N	TCGA-25-2398	OV	TCGA	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation altering degron motif	0.6312
p.H641N	DO31250	OV	ICGC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation altering degron motif	0.6312
p.S513G	TCGA-44-7660	LUAD	TCGA	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.1111
p.S513G	DO23834	LUAD	ICGC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.1111
p.R1584Q	TCGA-A5-A0G2	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.R1584Q	TCGA-AX-A05Z	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.R1584Q	TCGA-BK-A6W3	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.R1584Q	TCGA-BR-8680	STAD	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.R1584Q	DO47769	STAD	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.R1584Q	DO40884	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.R1584Q	DO50076	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.R1584Q	DO41235	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6218
p.S510I	TCGA-AP-A0LM	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.1944
p.S510I	DO43306	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.1944
p.S1861Y	TCGA-AP-A1DK	UCEC	TCGA	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1667
p.S1861Y	TCGA-AP-A1DK	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	1856:1860	Mutation rewiring degron network	0.3056
p.S1861Y	DO42033	UCEC	ICGC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1667
p.S1861Y	DO42033	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	1856:1860	Mutation rewiring degron network	0.3056
p.E508K	TCGA-AX-A1CE	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.25
p.E508K	DO42280	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.25
p.D498Y	TCGA-B5-A0JY	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.2778
p.D498Y	DO43041	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.2778
p.D500N	TCGA-B5-A3FA	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.5821
p.D500N	DO52402	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.5821
p.D500N	SIDM00150	Colorectal Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.5821
p.D500N	ACH-000969	Colon/Colorectal Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.5821
p.D500N	KM12	large intestine	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.5821
p.P1862H	TCGA-BK-A13B	UCEC	TCGA	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1389
p.P1862H	TCGA-BK-A13B	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	1856:1860	Mutation rewiring degron network	0.2778
p.P1862H	DO40825	UCEC	ICGC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1389
p.P1862H	DO40825	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	1856:1860	Mutation rewiring degron network	0.2778
p.V652I	TCGA-D3-A5GS	SKCM	TCGA	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1389
p.V652I	DO47706	SKCM	ICGC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1389
p.S640Y	TCGA-EO-A22R	UCEC	TCGA	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.3056
p.S640Y	DO42713	UCEC	ICGC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.3056
p.P2260T	TCGA-ER-A19Q	SKCM	TCGA	VNTPQKE	DEG_SCF_FBW7_2	2257:2263	Mutation altering degron motif	0.7031
p.P2260T	DO47497	SKCM	ICGC	VNTPQKE	DEG_SCF_FBW7_2	2257:2263	Mutation altering degron motif	0.7031
p.P651S	TCGA-F4-6703	COAD	TCGA	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1667
p.P651S	DO9908	COAD	ICGC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1667
p.S1576L	TCGA-FI-A2D0	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.1389
p.S1576L	DO43891	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.1389
p.R1573Q	TCGA-FI-A2D5	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.0556
p.R1573Q	DO41331	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.0556
p.R1573Q	ACH-001991	Primary	CCLE	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.0556
p.P1036H	TCGA-GN-A269	SKCM	TCGA	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation rewiring degron network	0.25
p.P1036H	DO37483	SKCM	ICGC	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation rewiring degron network	0.25
p.P1852L	TCGA-GN-A4U5	SKCM	TCGA	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation altering degron motif	0.7582
p.P1852L	DO51257	SKCM	ICGC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation altering degron motif	0.7582
p.A1055S	TCGA-HU-A4GY	STAD	TCGA	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation rewiring degron network	0.0556
p.A1055S	DO47901	STAD	ICGC	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation rewiring degron network	0.0556
p.A1055S	SIDM00273	Glioblastoma	GDSC	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation rewiring degron network	0.0556
p.A1055S	ACH-000756	Brain Cancer	CCLE	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation rewiring degron network	0.0556
p.A1055S	GI-1	central nervous system	COSMIC	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation rewiring degron network	0.0556
p.R1573W	TCGA-VS-A8QF	CESC	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.0556
p.R1573W	DO51629	CESC	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.0556
p.R1587I	TCGA-XF-AAML	BLCA	TCGA	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6991
p.R1587I	DO51933	BLCA	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.6991
p.V635I	DO222492	COCA	ICGC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1667
p.T1578M	DO222884	COCA	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.1944
p.E638K	DO234419	ESAD	ICGC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.25
p.N2252S	DO231984	LICA	ICGC	VNTPQKE	DEG_SCF_FBW7_2	2257:2263	Mutation rewiring degron network	0.1944
p.N512K	DO228976	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.1389
p.P2270T	DO228985	LICA	ICGC	VNTPQKE	DEG_SCF_FBW7_2	2257:2263	Mutation rewiring degron network	0.1389
p.D500E	DO229037	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.6758
p.A2256T	DO33888	PACA	ICGC	VNTPQKE	DEG_SCF_FBW7_2	2257:2263	Mutation rewiring degron network	0.3056
p.P1586A	DO229094	UTCA	ICGC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation altering degron motif	0.7503
p.E1593K	SIDM00422	Hodgkin's Lymphoma	GDSC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.2222
p.H641Q	SIDM01261	Breast Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation altering degron motif	0.647
p.H641Q	SIDM00730	Small Cell Lung Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation altering degron motif	0.647
p.S1869I	SIDM00656	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	1856:1860	Mutation rewiring degron network	0.0833
p.S1869I	SIDM00793	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	1856:1860	Mutation rewiring degron network	0.0833
p.S1869I	SIDM00641	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	1856:1860	Mutation rewiring degron network	0.0833
p.L1839R	SIDM00950	Pancreatic Carcinoma	GDSC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.0833
p.L1839R	ACH-000243	Pancreatic Cancer	CCLE	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.0833
p.L1839R	DAN-G	pancreas	COSMIC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.0833
p.S633G	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1111
p.S633G	SIDM00493	Other Solid Cancers	GDSC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1111
p.S633G	SIDM01591	Breast Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	641:645	Mutation rewiring degron network	0.1111
p.S501L	SIDM01220	Glioma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.6556
p.S501L	ACH-000760	Brain Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.6556
p.S501L	ACH-002269	Brain Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.6556
p.S501L	LNZTA3WT4	central nervous system	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation altering degron motif	0.6556
p.N1844Y	SIDM01133	Other Solid Cancers	GDSC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2222
p.N1844Y	ACH-002177	Lung Cancer	CCLE	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2222
p.N1844Y	NCI-H835	lung	COSMIC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2222
p.K1590N	SIDM00534	Colorectal Carcinoma	GDSC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.3056
p.K1590N	ACH-000986	Colon/Colorectal Cancer	CCLE	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.3056
p.K1590N	HT-115	large intestine	COSMIC	PRTPRST	DEG_SCF_FBW7_1	1583:1589	Mutation rewiring degron network	0.3056
p.T496A	SIDM01318	Hepatocellular Carcinoma	GDSC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.2222
p.K496R	KATOIII	stomach	COSMIC	DSSSGE	DEG_Kelch_Keap1_1	500:505	Mutation rewiring degron network	0.2222
p.E1852G	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LTPTPDSS	DEG_SCF_FBW7_1	1848:1855	Mutation altering degron motif	0.7199
p.S1045F	MDA-MB-415	breast	COSMIC	PLTPKKS	DEG_SCF_FBW7_1	1039:1045	Mutation altering degron motif	0.7982
p.L2264I	GI-1	central nervous system	COSMIC	VNTPQKE	DEG_SCF_FBW7_2	2257:2263	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

REV3L

UniProt ID: O60673

Entrez ID: 5980

Protein name: DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for REV3L in