DegronMD

Uniprot ID: O60673

Source protein: DNA polymerase zeta catalytic subunit

Source gene: REV3L

Class: DEG_SCF_FBW7_1

Location: 1583:1589

E3 ligase: FBXW7

DEGRON score: 0.972

ASA_SCORE: 107.5

COIL: 0.9381

CONS_SCORE: 0.285

DSS_SCORE: 0.831

HELIX: 0.0379

FCONS_SCORE: 1.0662

RIG_SCORE: 0.6121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1584Q	TCGA-A5-A0G2	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.R1584Q	TCGA-AX-A05Z	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.R1584Q	TCGA-BK-A6W3	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.R1584Q	TCGA-BR-8680	STAD	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.R1584Q	DO47769	STAD	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.R1584Q	DO40884	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.R1584Q	DO50076	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.R1584Q	DO41235	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.6218
p.S1576L	TCGA-FI-A2D0	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.1389
p.S1576L	DO43891	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.1389
p.R1573Q	TCGA-FI-A2D5	UCEC	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.0556
p.R1573Q	DO41331	UCEC	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.0556
p.R1573Q	ACH-001991	Primary	CCLE	PRTPRST	DEG_SCF_FBW7_1	0.0556
p.R1573W	TCGA-VS-A8QF	CESC	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.0556
p.R1573W	DO51629	CESC	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.0556
p.R1587I	TCGA-XF-AAML	BLCA	TCGA	PRTPRST	DEG_SCF_FBW7_1	0.6991
p.R1587I	DO51933	BLCA	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.6991
p.T1578M	DO222884	COCA	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.1944
p.P1586A	DO229094	UTCA	ICGC	PRTPRST	DEG_SCF_FBW7_1	0.7503
p.E1593K	SIDM00422	Hodgkin's Lymphoma	GDSC	PRTPRST	DEG_SCF_FBW7_1	0.2222
p.K1590N	SIDM00534	Colorectal Carcinoma	GDSC	PRTPRST	DEG_SCF_FBW7_1	0.3056
p.K1590N	ACH-000986	Colon/Colorectal Cancer	CCLE	PRTPRST	DEG_SCF_FBW7_1	0.3056
p.K1590N	HT-115	large_intestine	COSMIC	PRTPRST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SCF_FBW7_1	1583:1589	PRTPRST	FBXW7	0.972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons