DegronMD

Uniprot ID: O60673

Source protein: DNA polymerase zeta catalytic subunit

Source gene: REV3L

Class: DEG_SCF_FBW7_2

Location: 2257:2263

E3 ligase: FBXW7

DEGRON score: 0.8677

ASA_SCORE: 94.4429

COIL: 0.8314

CONS_SCORE: 0.2868

DSS_SCORE: 0.5241

HELIX: 0.1174

FCONS_SCORE: 0.8173

RIG_SCORE: 0.7376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2260T	TCGA-ER-A19Q	SKCM	TCGA	VNTPQKE	DEG_SCF_FBW7_2	0.7031
p.P2260T	DO47497	SKCM	ICGC	VNTPQKE	DEG_SCF_FBW7_2	0.7031
p.N2252S	DO231984	LICA	ICGC	VNTPQKE	DEG_SCF_FBW7_2	0.1944
p.P2270T	DO228985	LICA	ICGC	VNTPQKE	DEG_SCF_FBW7_2	0.1389
p.A2256T	DO33888	PACA	ICGC	VNTPQKE	DEG_SCF_FBW7_2	0.3056
p.L2264I	GI-1	central_nervous_system	COSMIC	VNTPQKE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SCF_FBW7_2	2257:2263	VNTPQKE	FBXW7	0.8677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons