DegronMD

Uniprot ID: O60673

Source protein: DNA polymerase zeta catalytic subunit

Source gene: REV3L

Class: DEG_SCF_FBW7_1

Location: 1039:1045

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 113.5571

COIL: 0.9609

CONS_SCORE: 0.2396

DSS_SCORE: 0.6753

HELIX: 0.0249

FCONS_SCORE: 0.9721

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1036H	TCGA-GN-A269	SKCM	TCGA	PLTPKKS	DEG_SCF_FBW7_1	0.25
p.P1036H	DO37483	SKCM	ICGC	PLTPKKS	DEG_SCF_FBW7_1	0.25
p.A1055S	TCGA-HU-A4GY	STAD	TCGA	PLTPKKS	DEG_SCF_FBW7_1	0.0556
p.A1055S	DO47901	STAD	ICGC	PLTPKKS	DEG_SCF_FBW7_1	0.0556
p.A1055S	SIDM00273	Glioblastoma	GDSC	PLTPKKS	DEG_SCF_FBW7_1	0.0556
p.A1055S	ACH-000756	Brain Cancer	CCLE	PLTPKKS	DEG_SCF_FBW7_1	0.0556
p.A1055S	GI-1	central_nervous_system	COSMIC	PLTPKKS	DEG_SCF_FBW7_1	0.0556
p.S1045F	MDA-MB-415	breast	COSMIC	PLTPKKS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SCF_FBW7_1	1039:1045	PLTPKKS	FBXW7	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons