DegronMD

Uniprot ID: O60673

Source protein: DNA polymerase zeta catalytic subunit

Source gene: REV3L

Class: DEG_SPOP_SBC_1

Location: 1856:1860

E3 ligase: SPOP

DEGRON score: 0.6142

ASA_SCORE: 93.38

COIL: 0.9196

CONS_SCORE: 0.2344

DSS_SCORE: 0.7963

HELIX: 0.0326

FCONS_SCORE: 1.0957

RIG_SCORE: 0.5197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1861Y	TCGA-AP-A1DK	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.3056
p.S1861Y	DO42033	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P1862H	TCGA-BK-A13B	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.2778
p.P1862H	DO40825	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2778
p.S1869I	SIDM00656	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.S1869I	SIDM00793	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.S1869I	SIDM00641	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons