DegronMD - Q9BYB0(SHANK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1139V	TCGA-27-1833	GBM	TCGA	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.1667
p.A1139V	DO12976	GBM	ICGC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.1667
p.R682M	TCGA-63-6202	LUSC	TCGA	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778
p.R682M	DO26560	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778
p.R682S	TCGA-63-6202	LUSC	TCGA	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778
p.R682S	DO26560	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778
p.S1381C	TCGA-AC-A23H	BRCA	TCGA	SSESGE	DEG_Kelch_Keap1_1	1386:1391	Mutation rewiring degron network	0.1944
p.S1381C	DO2401	BRCA	ICGC	SSESGE	DEG_Kelch_Keap1_1	1386:1391	Mutation rewiring degron network	0.1944
p.V674I	TCGA-AJ-A3EK	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.V674I	DO41584	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.A1127S	TCGA-BP-4162	KIRC	TCGA	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.3056
p.A1127S	DO20545	KIRC	ICGC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.3056
p.G688W	TCGA-CV-5441	HNSC	TCGA	APSTT	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7825
p.G688W	DO15671	HNSC	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7825
p.G792E	TCGA-D1-A163	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1667
p.G792E	DO41008	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1667
p.R357Q	TCGA-DF-A2KV	UCEC	TCGA	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.0833
p.R357Q	DO219771	UCEC	ICGC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.0833
p.R357Q	SIDM02015	Colorectal Carcinoma	GDSC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.0833
p.V343A	TCGA-EE-A2MI	SKCM	TCGA	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation altering degron motif	0.6936
p.V343A	DO37531	SKCM	ICGC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation altering degron motif	0.6936
p.P1120L	TCGA-ER-A19A	SKCM	TCGA	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.1111
p.P1120L	DO47425	SKCM	ICGC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.1111
p.D340N	TCGA-FS-A1ZM	SKCM	TCGA	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.25
p.D340N	DO37731	SKCM	ICGC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.25
p.A1136V	TCGA-G7-A8LB	KIRP	TCGA	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.25
p.A1136V	DO51553	KIRP	ICGC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.25
p.V677D	DO222995	BTCA	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.E1387G	DO8264	COAD	ICGC	SSESGE	DEG_Kelch_Keap1_1	1386:1391	Mutation altering degron motif	0.7199
p.R356W	DO230312	COCA	ICGC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.1111
p.R356W	DO27803	MALY	ICGC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.1111
p.A806T	DO234230	ESAD	ICGC	PRSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.A689V	DO234417	ESAD	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.A689V	DO233652	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.P1140L	DO233221	GACA	ICGC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.1389
p.G792R	DO233862	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1667
p.V677F	DO228948	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.S1380I	DO228952	LICA	ICGC	SSESGE	DEG_Kelch_Keap1_1	1386:1391	Mutation rewiring degron network	0.1667
p.V678L	DO228974	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1667
p.R690L	DO229018	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation blocking phosphorylation signal	0.7222
p.L789F	DO229029	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0833
p.M1398I	DO229026	LICA	ICGC	SSESGE	DEG_Kelch_Keap1_1	1386:1391	Mutation rewiring degron network	0.1389
p.T1394M	DO232224	PBCA	ICGC	SSESGE	DEG_Kelch_Keap1_1	1386:1391	Mutation rewiring degron network	0.25
p.R1125W	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.25
p.R1125W	SIDM01113	Other Sarcomas	GDSC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.25
p.R1125W	SU-DHL-8	NS	COSMIC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.25
p.R1125W	SK-UT-1	soft tissue	COSMIC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.25
p.R674C	SIDM00889	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.R674C	C-33-A	cervix	COSMIC	APSTT	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.V334D	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.0833
p.V334D	ACH-002222	Leukemia	CCLE	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.0833
p.V334D	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VVPFRE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.0833
p.R1137C	SIDM00783	Colorectal Carcinoma	GDSC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.2222
p.R1137C	HCT-116	large intestine	COSMIC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.2222
p.P1137S	ACH-000604	Leukemia	CCLE	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.2222
p.R1124C	ACH-000971	Colon/Colorectal Cancer	CCLE	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.2222
p.A812V	ACH-001145	Ovarian Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.R1119W	SK-UT-1	soft tissue	COSMIC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.0833
p.R1119W	SU-DHL-8	NS	COSMIC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation rewiring degron network	0.0833
p.L1399V	AN3-CA	endometrium	COSMIC	SSESGE	DEG_Kelch_Keap1_1	1386:1391	Mutation rewiring degron network	0.1111
p.R1131C	HCT-116	large intestine	COSMIC	PTPVHS	DEG_SCF_FBW7_1	1128:1133	Mutation altering degron motif	0.8301

Kaplan plot for SHANK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHANK3

UniProt ID: Q9BYB0

Entrez ID:

Protein name: SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHANK3 in