DegronMD

Uniprot ID: Q9BYB0

Source protein: SH3 and multiple ankyrin repeat domains protein 3

Source gene: SHANK3

Class: LIG_APCC_ABBA_1

Location: 343:348

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 79.85

COIL: 0.743

CONS_SCORE: 0.6188

DSS_SCORE: 0.4462

HELIX: 0.1388

FCONS_SCORE: 1.3315

RIG_SCORE: 0.768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R357Q	TCGA-DF-A2KV	UCEC	TCGA	VVPFRE	LIG_APCC_ABBA_1	0.0833
p.R357Q	DO219771	UCEC	ICGC	VVPFRE	LIG_APCC_ABBA_1	0.0833
p.R357Q	SIDM02015	Colorectal Carcinoma	GDSC	VVPFRE	LIG_APCC_ABBA_1	0.0833
p.V343A	TCGA-EE-A2MI	SKCM	TCGA	VVPFRE	LIG_APCC_ABBA_1	0.6936
p.V343A	DO37531	SKCM	ICGC	VVPFRE	LIG_APCC_ABBA_1	0.6936
p.D340N	TCGA-FS-A1ZM	SKCM	TCGA	VVPFRE	LIG_APCC_ABBA_1	0.25
p.D340N	DO37731	SKCM	ICGC	VVPFRE	LIG_APCC_ABBA_1	0.25
p.R356W	DO230312	COCA	ICGC	VVPFRE	LIG_APCC_ABBA_1	0.1111
p.R356W	DO27803	MALY	ICGC	VVPFRE	LIG_APCC_ABBA_1	0.1111
p.V334D	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VVPFRE	LIG_APCC_ABBA_1	0.0833
p.V334D	ACH-002222	Leukemia	CCLE	VVPFRE	LIG_APCC_ABBA_1	0.0833
p.V334D	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VVPFRE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	LIG_APCC_ABBA_1	343:348	VVPFRE	APC,CDC20,FZR1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons