DegronMD

Uniprot ID: Q9BYB0

Source protein: SH3 and multiple ankyrin repeat domains protein 3

Source gene: SHANK3

Class: DEG_SCF_FBW7_1

Location: 1128:1133

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 98.9333

COIL: 0.97

CONS_SCORE: 0.3847

DSS_SCORE: 0.7769

HELIX: 0.0127

FCONS_SCORE: 1.1799

RIG_SCORE: 0.5452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1139V	TCGA-27-1833	GBM	TCGA	PTPVHS	DEG_SCF_FBW7_1	0.1667
p.A1139V	DO12976	GBM	ICGC	PTPVHS	DEG_SCF_FBW7_1	0.1667
p.A1127S	TCGA-BP-4162	KIRC	TCGA	PTPVHS	DEG_SCF_FBW7_1	0.3056
p.A1127S	DO20545	KIRC	ICGC	PTPVHS	DEG_SCF_FBW7_1	0.3056
p.P1120L	TCGA-ER-A19A	SKCM	TCGA	PTPVHS	DEG_SCF_FBW7_1	0.1111
p.P1120L	DO47425	SKCM	ICGC	PTPVHS	DEG_SCF_FBW7_1	0.1111
p.A1136V	TCGA-G7-A8LB	KIRP	TCGA	PTPVHS	DEG_SCF_FBW7_1	0.25
p.A1136V	DO51553	KIRP	ICGC	PTPVHS	DEG_SCF_FBW7_1	0.25
p.P1140L	DO233221	GACA	ICGC	PTPVHS	DEG_SCF_FBW7_1	0.1389
p.R1125W	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPVHS	DEG_SCF_FBW7_1	0.25
p.R1125W	SIDM01113	Other Sarcomas	GDSC	PTPVHS	DEG_SCF_FBW7_1	0.25
p.R1125W	SU-DHL-8	NS	COSMIC	PTPVHS	DEG_SCF_FBW7_1	0.25
p.R1125W	SK-UT-1	soft_tissue	COSMIC	PTPVHS	DEG_SCF_FBW7_1	0.25
p.R1137C	SIDM00783	Colorectal Carcinoma	GDSC	PTPVHS	DEG_SCF_FBW7_1	0.2222
p.R1137C	HCT-116	large_intestine	COSMIC	PTPVHS	DEG_SCF_FBW7_1	0.2222
p.P1137S	ACH-000604	Leukemia	CCLE	PTPVHS	DEG_SCF_FBW7_1	0.2222
p.R1124C	ACH-000971	Colon/Colorectal Cancer	CCLE	PTPVHS	DEG_SCF_FBW7_1	0.2222
p.R1119W	SK-UT-1	soft_tissue	COSMIC	PTPVHS	DEG_SCF_FBW7_1	0.0833
p.R1119W	SU-DHL-8	NS	COSMIC	PTPVHS	DEG_SCF_FBW7_1	0.0833
p.R1131C	HCT-116	large_intestine	COSMIC	PTPVHS	DEG_SCF_FBW7_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SCF_FBW7_1	1128:1133	PTPVHS	FBXW7	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons