DegronMD

Uniprot ID: Q9BYB0

Source protein: SH3 and multiple ankyrin repeat domains protein 3

Source gene: SHANK3

Class: DEG_Kelch_Keap1_1

Location: 1386:1391

E3 ligase: KEAP1

DEGRON score: 0.9932

ASA_SCORE: 80.7333

COIL: 0.8383

CONS_SCORE: 0.346

DSS_SCORE: 0.5686

HELIX: 0.1072

FCONS_SCORE: 1.068

RIG_SCORE: 0.6002

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1387G	DO8264	COAD	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.7199
p.T1394M	DO232224	PBCA	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.25
p.S1381C	TCGA-AC-A23H	BRCA	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.1944
p.S1381C	DO2401	BRCA	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.1944
p.S1380I	DO228952	LICA	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.1667
p.M1398I	DO229026	LICA	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.1389
p.L1399V	AN3-CA	endometrium	COSMIC	SSESGE	DEG_Kelch_Keap1_1	0.1111

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKA4	A-kinase anchor protein 11	DEG_Kelch_Keap1_1	1176:1181	SSESGE	KEAP1	0.8442	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_Kelch_Keap1_1	1386:1391	SSESGE	KEAP1	0.9932	More...
Q9H2Y7	Zinc finger protein 106	DEG_Kelch_Keap1_1	1440:1445	SSESGE	KEAP1	0.9931	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons