DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SSESGE
Uniprot ID:
Q9BYB0
Source protein:
SH3 and multiple ankyrin repeat domains protein 3
Source gene:
SHANK3
Class:
DEG_Kelch_Keap1_1
Location:
1386:1391
E3 ligase:
KEAP1
DEGRON score:
0.9932
ASA_SCORE:
80.7333
COIL:
0.8383
CONS_SCORE:
0.346
DSS_SCORE:
0.5686
HELIX:
0.1072
FCONS_SCORE:
1.068
RIG_SCORE:
0.6002
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1381C
TCGA-AC-A23H
BRCA
TCGA
SSESGE
DEG_Kelch_Keap1_1
0.1944
p.S1381C
DO2401
BRCA
ICGC
SSESGE
DEG_Kelch_Keap1_1
0.1944
p.E1387G
DO8264
COAD
ICGC
SSESGE
DEG_Kelch_Keap1_1
0.7199
p.S1380I
DO228952
LICA
ICGC
SSESGE
DEG_Kelch_Keap1_1
0.1667
p.M1398I
DO229026
LICA
ICGC
SSESGE
DEG_Kelch_Keap1_1
0.1389
p.T1394M
DO232224
PBCA
ICGC
SSESGE
DEG_Kelch_Keap1_1
0.25
p.L1399V
AN3-CA
endometrium
COSMIC
SSESGE
DEG_Kelch_Keap1_1
0.1111
Drug responses associated with SHANK3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SSESGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BYB0
SH3 and multiple ankyrin repeat domains protein 3
DEG_Kelch_Keap1_1
1386:1391
SSESGE
KEAP1
0.9932
More...
Q9H2Y7
Zinc finger protein 106
DEG_Kelch_Keap1_1
1440:1445
SSESGE
KEAP1
0.9931
More...
Q9UKA4
A-kinase anchor protein 11
DEG_Kelch_Keap1_1
1176:1181
SSESGE
KEAP1
0.8442
More...