DegronMD

Uniprot ID: Q9UKA4

Source protein: A-kinase anchor protein 11

Source gene: AKAP11

Class: DEG_Kelch_Keap1_1

Location: 1176:1181

E3 ligase: KEAP1

DEGRON score: 0.8442

ASA_SCORE: 93.7167

COIL: 0.8327

CONS_SCORE: 0.5798

DSS_SCORE: 0.5414

HELIX: 0.1487

FCONS_SCORE: 0.9159

RIG_SCORE: 0.6058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1173G	TCGA-A5-A0G2	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.25
p.E1173G	DO41235	UCEC	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.25
p.S1176N	TCGA-AN-A0FN	BRCA	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.7069
p.S1176N	DO3828	BRCA	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.7069
p.V1185A	TCGA-D3-A2JP	SKCM	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.2222
p.V1185A	DO47407	SKCM	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.2222
p.K1188E	TCGA-EO-A22R	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.25
p.K1188E	DO42713	UCEC	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.25
p.L1170V	TCGA-EY-A1GS	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.1667
p.L1170V	DO43162	UCEC	ICGC	SSESGE	DEG_Kelch_Keap1_1	0.1667
p.R1168Q	SIDM01169	Ovarian Carcinoma	GDSC	SSESGE	DEG_Kelch_Keap1_1	0.1111
p.R1168Q	ACH-000885	Ovarian Cancer	CCLE	SSESGE	DEG_Kelch_Keap1_1	0.1111
p.R1168Q	TOV-21G	ovary	COSMIC	SSESGE	DEG_Kelch_Keap1_1	0.1111
p.S1177T	SIDM00312	Plasma Cell Myeloma	GDSC	SSESGE	DEG_Kelch_Keap1_1	0.6005
p.S1177T	ACH-000183	Myeloma	CCLE	SSESGE	DEG_Kelch_Keap1_1	0.6005
p.S1177T	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	SSESGE	DEG_Kelch_Keap1_1	0.6005
p.H1191Y	SIDM01609	Endometrial Carcinoma	GDSC	SSESGE	DEG_Kelch_Keap1_1	0.0556
p.H1191Y	ACH-000972	Endometrial/Uterine Cancer	CCLE	SSESGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_Kelch_Keap1_1	1386:1391	SSESGE	KEAP1	0.9932	More...
Q9H2Y7	Zinc finger protein 106	DEG_Kelch_Keap1_1	1440:1445	SSESGE	KEAP1	0.9931	More...
Q9UKA4	A-kinase anchor protein 11	DEG_Kelch_Keap1_1	1176:1181	SSESGE	KEAP1	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons