DegronMD

Uniprot ID: Q9H2Y7

Source protein: Zinc finger protein 106

Source gene: ZNF106

Class: DEG_Kelch_Keap1_1

Location: 1440:1445

E3 ligase: KEAP1

DEGRON score: 0.9931

ASA_SCORE: 73.1333

COIL: 0.7278

CONS_SCORE: 0.4424

DSS_SCORE: 0.7189

HELIX: 0.0128

FCONS_SCORE: 1.1183

RIG_SCORE: 0.5757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1454N	TCGA-B5-A11E	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.1944
p.S1450N	TCGA-D1-A1NY	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	0.1944
p.P1448A	SIDM00669	Pancreatic Carcinoma	GDSC	SSESGE	DEG_Kelch_Keap1_1	0.25
p.P1448A	HPAF-II	pancreas	COSMIC	SSESGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_Kelch_Keap1_1	1386:1391	SSESGE	KEAP1	0.9932	More...
Q9H2Y7	Zinc finger protein 106	DEG_Kelch_Keap1_1	1440:1445	SSESGE	KEAP1	0.9931	More...
Q9UKA4	A-kinase anchor protein 11	DEG_Kelch_Keap1_1	1176:1181	SSESGE	KEAP1	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons