DegronMD - Q9UKA4(AKAP11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H258R	TCGA-2Y-A9GT	LIHC	TCGA	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1667
p.H258R	DO219506	LIHC	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1667
p.S1139C	TCGA-33-4532	LUSC	TCGA	PATPPST	DEG_SCF_FBW7_1	1134:1140	Mutation altering degron motif	0.643
p.S1139C	DO26626	LUSC	ICGC	PATPPST	DEG_SCF_FBW7_1	1134:1140	Mutation altering degron motif	0.643
p.S1144P	TCGA-A5-A0G2	UCEC	TCGA	PATPPST	DEG_SCF_FBW7_1	1134:1140	Mutation rewiring degron network	0.2222
p.S1144P	DO41235	UCEC	ICGC	PATPPST	DEG_SCF_FBW7_1	1134:1140	Mutation rewiring degron network	0.2222
p.E1173G	TCGA-A5-A0G2	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.25
p.E1173G	DO41235	UCEC	ICGC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.25
p.S1176N	TCGA-AN-A0FN	BRCA	TCGA	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation altering degron motif	0.7069
p.S1176N	DO3828	BRCA	ICGC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation altering degron motif	0.7069
p.R435H	TCGA-AP-A051	UCEC	TCGA	DSGLFS	DEG_SCF_TRCP1_1	443:448	Mutation rewiring degron network	0.1111
p.R435H	DO42673	UCEC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	443:448	Mutation rewiring degron network	0.1111
p.S244P	TCGA-AP-A0LM	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.2222
p.S244P	DO43306	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.2222
p.S244L	TCGA-CR-7386	HNSC	TCGA	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.2222
p.S244L	DO14348	HNSC	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.2222
p.V1185A	TCGA-D3-A2JP	SKCM	TCGA	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.2222
p.V1185A	DO47407	SKCM	ICGC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.2222
p.K1188E	TCGA-EO-A22R	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation substituting flanking lysine	0.25
p.K1188E	DO42713	UCEC	ICGC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation substituting flanking lysine	0.25
p.P262H	TCGA-ER-A2NH	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0556
p.P262H	DO47683	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0556
p.L1170V	TCGA-EY-A1GS	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.1667
p.L1170V	DO43162	UCEC	ICGC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.1667
p.S252L	TCGA-GN-A269	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7667
p.S252L	DO37483	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7667
p.D1087G	TCGA-S9-A6WG	LGG	TCGA	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.0556
p.D1087G	DO50197	LGG	ICGC	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.0556
p.S249L	DO233164	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.6556
p.L256P	DO233766	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.2222
p.S456I	DO229031	LICA	ICGC	DSGLFS	DEG_SCF_TRCP1_1	443:448	Mutation blocking phosphorylation signal	0.5556
p.Q242R	DO231728	LINC	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1667
p.S448I	DO45165	LIRI	ICGC	DSGLFS	DEG_SCF_TRCP1_1	443:448	Mutation altering degron motif	0.8453
p.P1101S	DO220906	MELA	ICGC	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation altering degron motif	0.6752
p.S251F	DO33984	PACA	ICGC	PSTSS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.7982
p.R1110Q	DO35442	PACA	ICGC	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.1667
p.R1110Q	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.1667
p.R1110Q	ACH-000697	Lymphoma	CCLE	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.1667
p.R1110Q	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.1667
p.R441K	SIDM02031	Esophageal Carcinoma	GDSC	DSGLFS	DEG_SCF_TRCP1_1	443:448	Mutation rewiring degron network	0.2778
p.R1168Q	SIDM01169	Ovarian Carcinoma	GDSC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.1111
p.R1168Q	ACH-000885	Ovarian Cancer	CCLE	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.1111
p.R1168Q	TOV-21G	ovary	COSMIC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.1111
p.S1177T	SIDM00312	Plasma Cell Myeloma	GDSC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation altering degron motif	0.6005
p.S1177T	ACH-000183	Myeloma	CCLE	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation altering degron motif	0.6005
p.S1177T	L-363	haematopoietic and lymphoid tissue	COSMIC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation altering degron motif	0.6005
p.N1095S	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.2778
p.N1095S	ACH-000511	Lung Cancer	CCLE	IPDTPPST	DEG_SCF_FBW7_1	1097:1104	Mutation rewiring degron network	0.2778
p.H1191Y	SIDM01609	Endometrial Carcinoma	GDSC	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.0556
p.H1191Y	ACH-000972	Endometrial/Uterine Cancer	CCLE	SSESGE	DEG_Kelch_Keap1_1	1176:1181	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP11

UniProt ID: Q9UKA4

Entrez ID: 11215

Protein name: A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP11 in