DegronMD

Uniprot ID: Q9UKA4

Source protein: A-kinase anchor protein 11

Source gene: AKAP11

Class: DEG_SCF_FBW7_1

Location: 1097:1104

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 94.75

COIL: 0.9733

CONS_SCORE: 0.7155

DSS_SCORE: 0.6154

HELIX: 0.0101

FCONS_SCORE: 1.324

RIG_SCORE: 0.6749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1087G	TCGA-S9-A6WG	LGG	TCGA	IPDTPPST	DEG_SCF_FBW7_1	0.0556
p.D1087G	DO50197	LGG	ICGC	IPDTPPST	DEG_SCF_FBW7_1	0.0556
p.P1101S	DO220906	MELA	ICGC	IPDTPPST	DEG_SCF_FBW7_1	0.6752
p.R1110Q	DO35442	PACA	ICGC	IPDTPPST	DEG_SCF_FBW7_1	0.1667
p.R1110Q	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPDTPPST	DEG_SCF_FBW7_1	0.1667
p.R1110Q	ACH-000697	Lymphoma	CCLE	IPDTPPST	DEG_SCF_FBW7_1	0.1667
p.R1110Q	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	IPDTPPST	DEG_SCF_FBW7_1	0.1667
p.N1095S	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	IPDTPPST	DEG_SCF_FBW7_1	0.2778
p.N1095S	ACH-000511	Lung Cancer	CCLE	IPDTPPST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKA4	A-kinase anchor protein 11	DEG_SCF_FBW7_1	1097:1104	IPDTPPST	FBXW7	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons