DegronMD

Uniprot ID: Q9UKA4

Source protein: A-kinase anchor protein 11

Source gene: AKAP11

Class: DEG_SCF_FBW7_1

Location: 1134:1140

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 88.5

COIL: 0.9633

CONS_SCORE: 0.8392

DSS_SCORE: 0.6634

HELIX: 0.015

FCONS_SCORE: 1.2479

RIG_SCORE: 0.5678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1139C	TCGA-33-4532	LUSC	TCGA	PATPPST	DEG_SCF_FBW7_1	0.643
p.S1139C	DO26626	LUSC	ICGC	PATPPST	DEG_SCF_FBW7_1	0.643
p.S1144P	TCGA-A5-A0G2	UCEC	TCGA	PATPPST	DEG_SCF_FBW7_1	0.2222
p.S1144P	DO41235	UCEC	ICGC	PATPPST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKA4	A-kinase anchor protein 11	DEG_SCF_FBW7_1	1134:1140	PATPPST	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons