DegronMD

Uniprot ID: Q9UKA4

Source protein: A-kinase anchor protein 11

Source gene: AKAP11

Class: DEG_SCF_TRCP1_1

Location: 443:448

E3 ligase: BTRC

DEGRON score: 0.9996

ASA_SCORE: 67.2833

COIL: 0.7982

CONS_SCORE: 0.7541

DSS_SCORE: 0.5293

HELIX: 0.1288

FCONS_SCORE: 1.0444

RIG_SCORE: 0.6766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R435H	TCGA-AP-A051	UCEC	TCGA	DSGLFS	DEG_SCF_TRCP1_1	0.1111
p.R435H	DO42673	UCEC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.1111
p.S456I	DO229031	LICA	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.5556
p.S448I	DO45165	LIRI	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.8453
p.R441K	SIDM02031	Esophageal Carcinoma	GDSC	DSGLFS	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons