DegronMD - O75128(COBL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D568E	TCGA-29-1701	OV	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1389
p.D568E	TCGA-29-1701	OV	TCGA	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.0556
p.D568E	DO29830	OV	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1389
p.D568E	DO29830	OV	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.0556
p.S786I	TCGA-49-4514	LUAD	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1944
p.S786I	DO23818	LUAD	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1944
p.G765V	TCGA-53-7624	LUAD	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1667
p.G765V	DO25058	LUAD	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1667
p.R612H	TCGA-85-8277	LUSC	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.8244
p.R612H	DO26719	LUSC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.8244
p.P792L	TCGA-A3-3331	KIRC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.6471
p.A580V	TCGA-AA-3492	COAD	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.5825
p.A580V	DO6494	CLLE	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.5825
p.A580V	DO8224	COAD	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.5825
p.S761Y	TCGA-AP-A051	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.2778
p.S761Y	DO229035	LICA	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.2778
p.S761Y	DO42673	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.2778
p.E785K	TCGA-AP-A056	UCEC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1667
p.E785K	DO43971	UCEC	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1667
p.D402N	TCGA-AP-A05N	UCEC	TCGA	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.2222
p.D402N	DO40851	UCEC	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.2222
p.L752P	TCGA-AP-A1DK	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation altering degron motif	0.6471
p.L752P	DO42033	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation altering degron motif	0.6471
p.A744T	TCGA-AP-A1DV	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1389
p.A744T	DO43186	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1389
p.A628T	TCGA-AX-A05Z	UCEC	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.0833
p.A628T	DO40884	UCEC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.0833
p.A603T	TCGA-AX-A2HD	UCEC	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.1111
p.A603T	TCGA-BR-8487	STAD	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.1111
p.A603T	DO228353	MALY	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.1111
p.A603T	DO47867	STAD	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.1111
p.A603T	DO42608	UCEC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.1111
p.P797L	TCGA-BR-4362	STAD	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.6471
p.P797L	DO38336	STAD	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.6471
p.G746C	TCGA-BR-6452	STAD	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1944
p.G746C	DO38404	STAD	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1944
p.D553H	TCGA-CN-6995	HNSC	TCGA	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation altering degron motif	0.7688
p.D553H	DO14854	HNSC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation altering degron motif	0.7688
p.R612C	TCGA-CS-6670	LGG	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.8301
p.R612C	DO22161	LGG	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.8301
p.A788V	TCGA-EC-A1QX	UCEC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.25
p.A788V	DO42592	UCEC	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.25
p.S578F	TCGA-EE-A29M	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.6871
p.S578F	DO37404	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.6871
p.R789S	TCGA-EE-A29X	SKCM	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.2778
p.R789S	DO37595	SKCM	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.2778
p.G610E	TCGA-EE-A2M5	SKCM	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.3056
p.G610E	DO37425	SKCM	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.3056
p.S554L	TCGA-EE-A2MD	SKCM	TCGA	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation altering degron motif	0.7667
p.S554L	DO222434	MELA	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation altering degron motif	0.7667
p.S554L	DO37851	SKCM	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation altering degron motif	0.7667
p.S412F	TCGA-EE-A2MM	SKCM	TCGA	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.6871
p.S412F	DO222678	MELA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.6871
p.S412F	DO37770	SKCM	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.6871
p.E591K	TCGA-EE-A2MN	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1111
p.E591K	DO37423	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1111
p.G622E	TCGA-EE-A3AE	SKCM	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.25
p.G622E	DO37802	SKCM	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.25
p.S741G	TCGA-EM-A2CM	THCA	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation blocking phosphorylation signal	0.5
p.S741G	DO39228	THCA	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation blocking phosphorylation signal	0.5
p.E769K	TCGA-EO-A22U	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.0556
p.E769K	DO43755	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.0556
p.G571C	TCGA-ER-A195	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.2222
p.G571C	DO47712	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.2222
p.G765W	TCGA-ER-A1A1	SKCM	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1667
p.G765W	DO37413	SKCM	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.1667
p.N559S	TCGA-G3-A3CG	LIHC	TCGA	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.3056
p.N559S	DO22845	LIHC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.3056
p.N559S	ACH-002115	Bone Cancer	CCLE	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.3056
p.N559S	EW-18	bone	COSMIC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.3056
p.G781R	TCGA-NJ-A4YQ	LUAD	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.0556
p.G781R	DO218944	LUAD	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.0556
p.A614T	TCGA-RP-A693	SKCM	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.6028
p.A614T	DO51268	SKCM	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.6028
p.S753C	TCGA-VP-A879	PRAD	TCGA	SLSSSVPEA	DEG_COP1_1	751:759	Mutation altering degron motif	0.7541
p.S753C	DO51382	PRAD	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation altering degron motif	0.7541
p.T794S	TCGA-VT-A80G	SARC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.8227
p.T794S	DO220287	SARC	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.8227
p.H590Y	TCGA-WE-A8ZY	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1389
p.H590Y	DO51292	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1389
p.R400G	DO224892	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1667
p.R400G	DO52553	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1667
p.S417F	DO3874	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1944
p.S417P	DO3874	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1944
p.S793Y	DO222617	BTCA	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.6009
p.P422S	DO222867	BTCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.0556
p.S548P	DO7906	COAD	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.1944
p.A628V	DO8730	COAD	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.0833
p.A628V	DO233865	GACA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.0833
p.E546D	DO8264	COAD	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.1389
p.E546D	DO41020	UCEC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.1389
p.D577A	DO229010	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.6682
p.D577A	DO229013	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.6682
p.D577A	DO229016	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.6682
p.D577A	DO229003	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.6682
p.D577A	DO229005	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.6682
p.V607I	DO229010	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO229013	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO229016	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO229003	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO229005	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO229489	LAML	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO228941	LICA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO230999	LUSC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.V607I	DO52365	LUSC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.2222
p.R400C	DO50406	ESAD	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1667
p.G608R	DO233210	GACA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.25
p.G608R	DO232761	PBCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.25
p.A405T	DO233760	GACA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.3056
p.T800M	DO233748	GACA	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.2778
p.P763T	DO228952	LICA	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.2222
p.H404N	DO228952	LICA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.2778
p.A628E	DO229018	LICA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.0833
p.P757T	DO229022	LICA	ICGC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation altering degron motif	0.7031
p.Q588K	DO229031	LICA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1944
p.H404P	DO23394	LINC	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.2778
p.D549A	DO45137	LIRI	ICGC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.2222
p.S400L	DO228222	MALY	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1667
p.P629L	DO220851	MELA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation rewiring degron network	0.0556
p.E398K	DO220911	MELA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.G571D	DO222567	MELA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.2222
p.G409E	SIDM00545	Melanoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.7199
p.G409E	Mewo	skin	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.7199
p.G409R	SIDM00545	Melanoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.7568
p.N751K	SIDM00080	Melanoma	GDSC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation altering degron motif	0.6918
p.N751K	SK-MEL-5	skin	COSMIC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation altering degron motif	0.6918
p.G591S	SIDM00113	Kidney Carcinoma	GDSC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1111
p.G591S	SIDM00799	Glioblastoma	GDSC	RRDSLAPLQ	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1111
p.Q750K	SIDM01245	T-Lymphoblastic Leukemia	GDSC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.3056
p.Q750K	BE-13	haematopoietic and lymphoid tissue	COSMIC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.3056
p.A551V	SIDM00120	Prostate Carcinoma	GDSC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.2778
p.A551V	DU-145	prostate	COSMIC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.2778
p.E398G	SIDM01078	Small Cell Lung Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.E398G	SHP-77	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.N616S	SIDM00197	Ewing's Sarcoma	GDSC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.7069
p.N616S	EW-18	bone	COSMIC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.7069
p.D400H	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1667
p.D400H	HCC-78	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1667
p.E415V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.25
p.E415V	NCI-H650	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.25
p.D398N	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.D398N	SIDM00898	Breast Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.D398N	SIDM00541	Colorectal Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.D398N	HT55	large intestine	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.D398N	AU565	breast	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.D398N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.V797E	SIDM00699	Small Cell Lung Carcinoma	GDSC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.7693
p.V797E	NCI-H2141	lung	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.7693
p.R547P	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation rewiring degron network	0.1667
p.L783F	SIDM00150	Colorectal Carcinoma	GDSC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1111
p.L783F	KM12	large intestine	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1111
p.S396I	ACH-000707	Lymphoma	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.0556
p.I618S	ACH-000848	Liver Cancer	CCLE	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.7341
p.I618S	JHH-7	liver	COSMIC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.7341
p.P413A	ACH-000869	Lung Cancer	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.3056
p.P413A	NCI-H1568	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.3056
p.P413H	ACH-000954	Endometrial/Uterine Cancer	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.3056
p.E760K	ACH-000987	Skin Cancer	CCLE	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.3056
p.E760K	Mewo	skin	COSMIC	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.3056
p.E804D	ACH-000991	Colon/Colorectal Cancer	CCLE	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1667
p.E804D	SNU-81	large intestine	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1667
p.F557L	ACH-001694	Head and Neck Cancer	CCLE	DSGLFS	DEG_SCF_TRCP1_1	553:558	Mutation altering degron motif	0.587
p.R768G	ACH-001793	Liposarcoma	CCLE	SLSSSVPEA	DEG_COP1_1	751:759	Mutation rewiring degron network	0.0833
p.D420G	ACH-001991	Primary	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.R612G	ACH-002396	Bone Cancer	CCLE	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.7568
p.R612G	Sarc9371	bone	COSMIC	IRVALSNIS	DEG_APCC_DBOX_1	611:619	Mutation altering degron motif	0.7568
p.T798R	SNU-61	large intestine	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.8987
p.T798R	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.8987

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COBL

UniProt ID: O75128

Entrez ID: 23242

Protein name: Protein cordon-bleu

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COBL in