DegronMD

Uniprot ID: O75128

Source protein: Protein cordon-bleu

Source gene: COBL

Class: DEG_SCF_TRCP1_1

Location: 406:412

E3 ligase: BTRC

DEGRON score: 0.7785

ASA_SCORE: 83.5143

COIL: 0.9024

CONS_SCORE: 0.4422

DSS_SCORE: 0.6186

HELIX: 0.0516

FCONS_SCORE: 1.0472

RIG_SCORE: 0.659

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D402N	TCGA-AP-A05N	UCEC	TCGA	DSGVMSS	DEG_SCF_TRCP1_1	0.2222
p.D402N	DO40851	UCEC	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.2222
p.S412F	TCGA-EE-A2MM	SKCM	TCGA	DSGVMSS	DEG_SCF_TRCP1_1	0.6871
p.S412F	DO222678	MELA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.6871
p.S412F	DO37770	SKCM	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.6871
p.R400G	DO224892	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.1667
p.R400G	DO52553	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.1667
p.S417F	DO3874	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.1944
p.S417P	DO3874	BRCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.1944
p.P422S	DO222867	BTCA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.0556
p.R400C	DO50406	ESAD	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.1667
p.A405T	DO233760	GACA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.3056
p.H404N	DO228952	LICA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.2778
p.H404P	DO23394	LINC	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.2778
p.S400L	DO228222	MALY	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.1667
p.E398K	DO220911	MELA	ICGC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.G409E	SIDM00545	Melanoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.7199
p.G409E	Mewo	skin	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.7199
p.G409R	SIDM00545	Melanoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.7568
p.E398G	SIDM01078	Small Cell Lung Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.E398G	SHP-77	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.D400H	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.1667
p.D400H	HCC-78	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.1667
p.E415V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.25
p.E415V	NCI-H650	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.25
p.D398N	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.D398N	SIDM00898	Breast Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.D398N	SIDM00541	Colorectal Carcinoma	GDSC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.D398N	HT55	large_intestine	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.D398N	AU565	breast	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.D398N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.1111
p.S396I	ACH-000707	Lymphoma	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	0.0556
p.P413A	ACH-000869	Lung Cancer	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	0.3056
p.P413A	NCI-H1568	lung	COSMIC	DSGVMSS	DEG_SCF_TRCP1_1	0.3056
p.P413H	ACH-000954	Endometrial/Uterine Cancer	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	0.3056
p.D420G	ACH-001991	Primary	CCLE	DSGVMSS	DEG_SCF_TRCP1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVMSS

Degron related mutations and impact score

Drug responses associated with COBL mutations

All proteins holding degron of DSGVMSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75128	Protein cordon-bleu	DEG_SCF_TRCP1_1	406:412	DSGVMSS	BTRC	0.7785	More...