DegronMD

Uniprot ID: O75128

Source protein: Protein cordon-bleu

Source gene: COBL

Class: DEG_SCF_FBW7_1

Location: 791:798

E3 ligase: FBXW7

DEGRON score: 0.9778

ASA_SCORE: 91.6

COIL: 0.9614

CONS_SCORE: 0.3889

DSS_SCORE: 0.862

HELIX: 0.0138

FCONS_SCORE: 1.0588

RIG_SCORE: 0.5159

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S786I	TCGA-49-4514	LUAD	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.1944
p.S786I	DO23818	LUAD	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.1944
p.P792L	TCGA-A3-3331	KIRC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.6471
p.E785K	TCGA-AP-A056	UCEC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.1667
p.E785K	DO43971	UCEC	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.1667
p.P797L	TCGA-BR-4362	STAD	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.6471
p.P797L	DO38336	STAD	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.6471
p.A788V	TCGA-EC-A1QX	UCEC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.25
p.A788V	DO42592	UCEC	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.25
p.R789S	TCGA-EE-A29X	SKCM	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.2778
p.R789S	DO37595	SKCM	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.2778
p.G781R	TCGA-NJ-A4YQ	LUAD	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.0556
p.G781R	DO218944	LUAD	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.0556
p.T794S	TCGA-VT-A80G	SARC	TCGA	PPSTPVPT	DEG_SCF_FBW7_1	0.8227
p.T794S	DO220287	SARC	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.8227
p.S793Y	DO222617	BTCA	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.6009
p.T800M	DO233748	GACA	ICGC	PPSTPVPT	DEG_SCF_FBW7_1	0.2778
p.V797E	SIDM00699	Small Cell Lung Carcinoma	GDSC	PPSTPVPT	DEG_SCF_FBW7_1	0.7693
p.V797E	NCI-H2141	lung	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	0.7693
p.L783F	SIDM00150	Colorectal Carcinoma	GDSC	PPSTPVPT	DEG_SCF_FBW7_1	0.1111
p.L783F	KM12	large_intestine	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	0.1111
p.E804D	ACH-000991	Colon/Colorectal Cancer	CCLE	PPSTPVPT	DEG_SCF_FBW7_1	0.1667
p.E804D	SNU-81	large_intestine	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	0.1667
p.T798R	SNU-61	large_intestine	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	0.8987
p.T798R	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PPSTPVPT	DEG_SCF_FBW7_1	0.8987

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75128	Protein cordon-bleu	DEG_SCF_FBW7_1	791:798	PPSTPVPT	FBXW7	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTPVPT

Degron related mutations and impact score

Drug responses associated with COBL mutations

All proteins holding degron of PPSTPVPT