DegronMD

Uniprot ID: O75128

Source protein: Protein cordon-bleu

Source gene: COBL

Class: DEG_SCF_TRCP1_1

Location: 553:558

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 75.65

COIL: 0.7442

CONS_SCORE: 0.4404

DSS_SCORE: 0.5347

HELIX: 0.218

FCONS_SCORE: 1.0356

RIG_SCORE: 0.7327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D568E	TCGA-29-1701	OV	TCGA	DSGLFS	DEG_SCF_TRCP1_1	0.0556
p.D568E	DO29830	OV	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.0556
p.D553H	TCGA-CN-6995	HNSC	TCGA	DSGLFS	DEG_SCF_TRCP1_1	0.7688
p.D553H	DO14854	HNSC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.7688
p.S554L	TCGA-EE-A2MD	SKCM	TCGA	DSGLFS	DEG_SCF_TRCP1_1	0.7667
p.S554L	DO222434	MELA	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.7667
p.S554L	DO37851	SKCM	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.7667
p.N559S	TCGA-G3-A3CG	LIHC	TCGA	DSGLFS	DEG_SCF_TRCP1_1	0.3056
p.N559S	DO22845	LIHC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.3056
p.N559S	ACH-002115	Bone Cancer	CCLE	DSGLFS	DEG_SCF_TRCP1_1	0.3056
p.N559S	EW-18	bone	COSMIC	DSGLFS	DEG_SCF_TRCP1_1	0.3056
p.S548P	DO7906	COAD	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.1944
p.E546D	DO8264	COAD	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.1389
p.E546D	DO41020	UCEC	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.1389
p.D549A	DO45137	LIRI	ICGC	DSGLFS	DEG_SCF_TRCP1_1	0.2222
p.A551V	SIDM00120	Prostate Carcinoma	GDSC	DSGLFS	DEG_SCF_TRCP1_1	0.2778
p.A551V	DU-145	prostate	COSMIC	DSGLFS	DEG_SCF_TRCP1_1	0.2778
p.R547P	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DSGLFS	DEG_SCF_TRCP1_1	0.1667
p.F557L	ACH-001694	Head and Neck Cancer	CCLE	DSGLFS	DEG_SCF_TRCP1_1	0.587

DegronMD: protein-targeted degradation, mutation and drug response to degrons