DegronMD

Uniprot ID: O75128

Source protein: Protein cordon-bleu

Source gene: COBL

Class: DEG_APCC_DBOX_1

Location: 575:583

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9887

ASA_SCORE: 94.6444

COIL: 0.7047

CONS_SCORE: 0.3904

DSS_SCORE: 0.6833

HELIX: 0.2524

FCONS_SCORE: 1.055

RIG_SCORE: 0.643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D568E	TCGA-29-1701	OV	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1389
p.D568E	DO29830	OV	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1389
p.A580V	TCGA-AA-3492	COAD	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	0.5825
p.A580V	DO6494	CLLE	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.5825
p.A580V	DO8224	COAD	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.5825
p.S578F	TCGA-EE-A29M	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	0.6871
p.S578F	DO37404	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.6871
p.E591K	TCGA-EE-A2MN	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1111
p.E591K	DO37423	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1111
p.G571C	TCGA-ER-A195	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	0.2222
p.G571C	DO47712	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.2222
p.H590Y	TCGA-WE-A8ZY	SKCM	TCGA	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1389
p.H590Y	DO51292	SKCM	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1389
p.D577A	DO229010	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.6682
p.D577A	DO229013	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.6682
p.D577A	DO229016	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.6682
p.D577A	DO229003	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.6682
p.D577A	DO229005	COCA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.6682
p.Q588K	DO229031	LICA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1944
p.G571D	DO222567	MELA	ICGC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.2222
p.G591S	SIDM00113	Kidney Carcinoma	GDSC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1111
p.G591S	SIDM00799	Glioblastoma	GDSC	RRDSLAPLQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75128	Protein cordon-bleu	DEG_APCC_DBOX_1	575:583	RRDSLAPLQ	APC,CDC20,FZR1	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons