DegronMD

Uniprot ID: O75128

Source protein: Protein cordon-bleu

Source gene: COBL

Class: DEG_COP1_1

Location: 751:759

E3 ligase: COP1

DEGRON score: 0.9897

ASA_SCORE: 88.0778

COIL: 0.8862

CONS_SCORE: 0.3695

DSS_SCORE: 0.3499

HELIX: 0.0692

FCONS_SCORE: 0.8689

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G765V	TCGA-53-7624	LUAD	TCGA	SLSSSVPEA	DEG_COP1_1	0.1667
p.G765V	DO25058	LUAD	ICGC	SLSSSVPEA	DEG_COP1_1	0.1667
p.S761Y	TCGA-AP-A051	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	0.2778
p.S761Y	DO229035	LICA	ICGC	SLSSSVPEA	DEG_COP1_1	0.2778
p.S761Y	DO42673	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	0.2778
p.L752P	TCGA-AP-A1DK	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	0.6471
p.L752P	DO42033	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	0.6471
p.A744T	TCGA-AP-A1DV	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	0.1389
p.A744T	DO43186	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	0.1389
p.G746C	TCGA-BR-6452	STAD	TCGA	SLSSSVPEA	DEG_COP1_1	0.1944
p.G746C	DO38404	STAD	ICGC	SLSSSVPEA	DEG_COP1_1	0.1944
p.S741G	TCGA-EM-A2CM	THCA	TCGA	SLSSSVPEA	DEG_COP1_1	0.5
p.S741G	DO39228	THCA	ICGC	SLSSSVPEA	DEG_COP1_1	0.5
p.E769K	TCGA-EO-A22U	UCEC	TCGA	SLSSSVPEA	DEG_COP1_1	0.0556
p.E769K	DO43755	UCEC	ICGC	SLSSSVPEA	DEG_COP1_1	0.0556
p.G765W	TCGA-ER-A1A1	SKCM	TCGA	SLSSSVPEA	DEG_COP1_1	0.1667
p.G765W	DO37413	SKCM	ICGC	SLSSSVPEA	DEG_COP1_1	0.1667
p.S753C	TCGA-VP-A879	PRAD	TCGA	SLSSSVPEA	DEG_COP1_1	0.7541
p.S753C	DO51382	PRAD	ICGC	SLSSSVPEA	DEG_COP1_1	0.7541
p.P763T	DO228952	LICA	ICGC	SLSSSVPEA	DEG_COP1_1	0.2222
p.P757T	DO229022	LICA	ICGC	SLSSSVPEA	DEG_COP1_1	0.7031
p.N751K	SIDM00080	Melanoma	GDSC	SLSSSVPEA	DEG_COP1_1	0.6918
p.N751K	SK-MEL-5	skin	COSMIC	SLSSSVPEA	DEG_COP1_1	0.6918
p.Q750K	SIDM01245	T-Lymphoblastic Leukemia	GDSC	SLSSSVPEA	DEG_COP1_1	0.3056
p.Q750K	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	SLSSSVPEA	DEG_COP1_1	0.3056
p.E760K	ACH-000987	Skin Cancer	CCLE	SLSSSVPEA	DEG_COP1_1	0.3056
p.E760K	Mewo	skin	COSMIC	SLSSSVPEA	DEG_COP1_1	0.3056
p.R768G	ACH-001793	Liposarcoma	CCLE	SLSSSVPEA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75128	Protein cordon-bleu	DEG_COP1_1	751:759	SLSSSVPEA	COP1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SLSSSVPEA

Degron related mutations and impact score

Drug responses associated with COBL mutations

All proteins holding degron of SLSSSVPEA