DegronMD

Uniprot ID: O75128

Source protein: Protein cordon-bleu

Source gene: COBL

Class: DEG_APCC_DBOX_1

Location: 611:619

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6079

ASA_SCORE: 83.9333

COIL: 0.7089

CONS_SCORE: 0.3571

DSS_SCORE: 0.4256

HELIX: 0.0566

FCONS_SCORE: 1.0345

RIG_SCORE: 0.7581

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R612H	TCGA-85-8277	LUSC	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.8244
p.R612H	DO26719	LUSC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.8244
p.A628T	TCGA-AX-A05Z	UCEC	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.0833
p.A628T	DO40884	UCEC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.0833
p.A603T	TCGA-AX-A2HD	UCEC	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.1111
p.A603T	TCGA-BR-8487	STAD	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.1111
p.A603T	DO228353	MALY	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.1111
p.A603T	DO47867	STAD	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.1111
p.A603T	DO42608	UCEC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.1111
p.R612C	TCGA-CS-6670	LGG	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.8301
p.R612C	DO22161	LGG	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.8301
p.G610E	TCGA-EE-A2M5	SKCM	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.3056
p.G610E	DO37425	SKCM	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.3056
p.G622E	TCGA-EE-A3AE	SKCM	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.25
p.G622E	DO37802	SKCM	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.25
p.A614T	TCGA-RP-A693	SKCM	TCGA	IRVALSNIS	DEG_APCC_DBOX_1	0.6028
p.A614T	DO51268	SKCM	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.6028
p.A628V	DO8730	COAD	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.0833
p.A628V	DO233865	GACA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.0833
p.V607I	DO229010	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO229013	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO229016	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO229003	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO229005	COCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO229489	LAML	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO228941	LICA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO230999	LUSC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.V607I	DO52365	LUSC	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.2222
p.G608R	DO233210	GACA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.25
p.G608R	DO232761	PBCA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.25
p.A628E	DO229018	LICA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.0833
p.P629L	DO220851	MELA	ICGC	IRVALSNIS	DEG_APCC_DBOX_1	0.0556
p.N616S	SIDM00197	Ewing's Sarcoma	GDSC	IRVALSNIS	DEG_APCC_DBOX_1	0.7069
p.N616S	EW-18	bone	COSMIC	IRVALSNIS	DEG_APCC_DBOX_1	0.7069
p.I618S	ACH-000848	Liver Cancer	CCLE	IRVALSNIS	DEG_APCC_DBOX_1	0.7341
p.I618S	JHH-7	liver	COSMIC	IRVALSNIS	DEG_APCC_DBOX_1	0.7341
p.R612G	ACH-002396	Bone Cancer	CCLE	IRVALSNIS	DEG_APCC_DBOX_1	0.7568
p.R612G	Sarc9371	bone	COSMIC	IRVALSNIS	DEG_APCC_DBOX_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRVALSNIS

Degron related mutations and impact score

Drug responses associated with COBL mutations

All proteins holding degron of IRVALSNIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75128	Protein cordon-bleu	DEG_APCC_DBOX_1	611:619	IRVALSNIS	APC,CDC20,FZR1	0.6079	More...