DegronMD - Q9H2Y7(ZNF106)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1310F	TCGA-06-5416	GBM	TCGA	ACTSS	DEG_SPOP_SBC_1	1306:1310	Mutation altering degron motif	0.7982
p.L455F	TCGA-18-3409	LUSC	TCGA	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.0833
p.L455F	DO26444	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.0833
p.S875C	TCGA-60-2714	LUSC	TCGA	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.1111
p.R1469H	TCGA-A5-A1OF	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation rewiring degron network	0.1667
p.R1469H	TCGA-DI-A1BU	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation rewiring degron network	0.1667
p.T1398I	TCGA-AA-A02R	COAD	TCGA	VTTST	DEG_SPOP_SBC_1	1396:1400	Mutation altering degron motif	0.8189
p.S1310Y	TCGA-AX-A0J0	UCEC	TCGA	ACTSS	DEG_SPOP_SBC_1	1306:1310	Mutation altering degron motif	0.712
p.R1405M	TCGA-AZ-4315	COAD	TCGA	VTTST	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1944
p.K1454N	TCGA-B5-A11E	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	1440:1445	Mutation substituting flanking lysine	0.1944
p.Y874H	TCGA-CK-5916	COAD	TCGA	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.0833
p.S1450N	TCGA-D1-A1NY	UCEC	TCGA	SSESGE	DEG_Kelch_Keap1_1	1440:1445	Mutation rewiring degron network	0.1944
p.T1467M	TCGA-DF-A2KU	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation rewiring degron network	0.1111
p.T1467M	TCGA-HU-A4GU	STAD	TCGA	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation rewiring degron network	0.1111
p.T1467M	SIDM00980	Gastric Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation rewiring degron network	0.1111
p.T1467M	23132-87	stomach	COSMIC	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation rewiring degron network	0.1111
p.F876L	TCGA-E6-A1LX	UCEC	TCGA	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.1389
p.P456S	TCGA-EE-A2MJ	SKCM	TCGA	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.0556
p.P456S	DO38099	SKCM	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.0556
p.R1484H	TCGA-T9-A92H	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation rewiring degron network	0.1944
p.T1478N	TCGA-UY-A78N	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	1475:1479	Mutation altering degron motif	0.7055
p.R885W	DO48576	BLCA	ICGC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation altering degron motif	0.8634
p.Q894R	DO9756	COAD	ICGC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.1389
p.T434A	DO230309	COCA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.1944
p.P438H	DO233855	GACA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.3056
p.E454G	DO22237	LGG	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.1111
p.P444T	DO228948	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation altering degron motif	0.7031
p.P456Q	DO229018	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.0556
p.Q440K	DO229019	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation altering degron motif	0.5833
p.Q440K	DO229045	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation altering degron motif	0.5833
p.Q436K	DO229045	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.25
p.E877K	DO23338	LINC	ICGC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.1667
p.P453S	DO230950	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.1389
p.P453S	DO224638	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.1389
p.S452F	DO26444	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation blocking phosphorylation signal	0.6111
p.P438L	DO220884	MELA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.3056
p.I878V	DO46657	PAAD	ICGC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation blocking phosphorylation signal	0.6389
p.G896D	DO34680	PACA	ICGC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.0833
p.S452P	DO219881	SKCA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation blocking phosphorylation signal	0.6111
p.S888G	DO51268	SKCM	ICGC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.3056
p.G883C	DO47789	STAD	ICGC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation altering degron motif	0.6489
p.V443A	DO42023	UCEC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation altering degron motif	0.6936
p.A1387D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VTTST	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.0833
p.A1387D	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VTTST	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.0833
p.A1387D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.0833
p.P1448A	SIDM00669	Pancreatic Carcinoma	GDSC	SSESGE	DEG_Kelch_Keap1_1	1440:1445	Mutation rewiring degron network	0.25
p.P1448A	HPAF-II	pancreas	COSMIC	SSESGE	DEG_Kelch_Keap1_1	1440:1445	Mutation rewiring degron network	0.25
p.G881A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.2778
p.G881A	H513	pleura	COSMIC	GKENE	DEG_APCC_KENBOX_2	883:887	Mutation rewiring degron network	0.2778
p.P1297A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ACTSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.0833
p.P1297A	SIDM01689	B-Lymphoblastic Leukemia	GDSC	ACTSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.0833
p.S449L	SIDM00359	Colorectal Carcinoma	GDSC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.25
p.S449L	ACH-000565	Colon/Colorectal Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.25
p.S449L	RCM-1	large intestine	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.25
p.T430S	ACH-000178	Pancreatic Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.0833
p.T430S	Hs766T	pancreas	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.0833
p.K450T	ACH-000898	Gastric Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.2222
p.S441R	ACH-000991	Colon/Colorectal Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation altering degron motif	0.7427
p.S441R	SNU-81	large intestine	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation altering degron motif	0.7427
p.S452Y	ACH-001328	Skin Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation blocking phosphorylation signal	0.6111
p.S452Y	A431	skin	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation blocking phosphorylation signal	0.6111
p.L435I	ACH-001513	Cervical Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.2222
p.E437Q	ACH-001842	Bile Duct Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	439:446	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF106

UniProt ID: Q9H2Y7

Entrez ID: 64397

Protein name: Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF106 in