DegronMD

Uniprot ID: Q9H2Y7

Source protein: Zinc finger protein 106

Source gene: ZNF106

Class: DEG_APCC_KENBOX_2

Location: 883:887

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9667

ASA_SCORE: 98.94

COIL: 0.8028

CONS_SCORE: 0.3557

DSS_SCORE: 0.6346

HELIX: 0.1242

FCONS_SCORE: 1.0507

RIG_SCORE: 0.6156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S875C	TCGA-60-2714	LUSC	TCGA	GKENE	DEG_APCC_KENBOX_2	0.1111
p.Y874H	TCGA-CK-5916	COAD	TCGA	GKENE	DEG_APCC_KENBOX_2	0.0833
p.F876L	TCGA-E6-A1LX	UCEC	TCGA	GKENE	DEG_APCC_KENBOX_2	0.1389
p.R885W	DO48576	BLCA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.8634
p.Q894R	DO9756	COAD	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.E877K	DO23338	LINC	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1667
p.I878V	DO46657	PAAD	ICGC	GKENE	DEG_APCC_KENBOX_2	0.6389
p.G896D	DO34680	PACA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.0833
p.S888G	DO51268	SKCM	ICGC	GKENE	DEG_APCC_KENBOX_2	0.3056
p.G883C	DO47789	STAD	ICGC	GKENE	DEG_APCC_KENBOX_2	0.6489
p.G881A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.2778
p.G881A	H513	pleura	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94985	Calsyntenin-1	DEG_APCC_KENBOX_2	896:900	GKENE	APC,CDC20,FZR1	0.6765	More...
Q9H2Y7	Zinc finger protein 106	DEG_APCC_KENBOX_2	883:887	GKENE	APC,CDC20,FZR1	0.9667	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	734:738	GKENE	APC,CDC20,FZR1	0.7023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons