DegronMD

Uniprot ID: O94985

Source protein: Calsyntenin-1

Source gene: CLSTN1

Class: DEG_APCC_KENBOX_2

Location: 896:900

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6765

ASA_SCORE: 99.38

COIL: 0.7132

CONS_SCORE: 0.3922

DSS_SCORE: 0.5841

HELIX: 0.2518

FCONS_SCORE: 0.7743

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P895H	DO47578	SKCM	ICGC	GKENE	DEG_APCC_KENBOX_2	0.3056
p.G896W	SIDM00518	Mesothelioma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.6714
p.G896W	ACH-002136	Lung Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	0.6714
p.G896W	H290	pleura	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.6714
p.V902I	EN	endometrium	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.2778
p.G886W	H290	pleura	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94985	Calsyntenin-1	DEG_APCC_KENBOX_2	896:900	GKENE	APC,CDC20,FZR1	0.6765	More...
Q9H2Y7	Zinc finger protein 106	DEG_APCC_KENBOX_2	883:887	GKENE	APC,CDC20,FZR1	0.9667	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	734:738	GKENE	APC,CDC20,FZR1	0.7023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons