DegronMD

Uniprot ID: Q9NQW8

Source protein: Cyclic nucleotide-gated cation channel beta-3

Source gene: CNGB3

Class: DEG_APCC_KENBOX_2

Location: 734:738

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7023

ASA_SCORE: 109.58

COIL: 0.761

CONS_SCORE: 0.5158

DSS_SCORE: 0.7167

HELIX: 0.2242

FCONS_SCORE: 1.0421

RIG_SCORE: 0.5565

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E736Q	TCGA-33-4532	LUSC	TCGA	GKENE	DEG_APCC_KENBOX_2	0.6744
p.E736Q	DO26626	LUSC	ICGC	GKENE	DEG_APCC_KENBOX_2	0.6744
p.G734V	TCGA-36-2545	OV	TCGA	GKENE	DEG_APCC_KENBOX_2	0.6421
p.G734V	DO28015	OV	ICGC	GKENE	DEG_APCC_KENBOX_2	0.6421
p.P746Q	TCGA-37-4135	LUSC	TCGA	GKENE	DEG_APCC_KENBOX_2	0.1111
p.P746Q	DO229028	LICA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1111
p.P746Q	DO26806	LUSC	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1111
p.E729Q	TCGA-78-7156	LUAD	TCGA	GKENE	DEG_APCC_KENBOX_2	0.1944
p.E729Q	TCGA-GV-A3QF	BLCA	TCGA	GKENE	DEG_APCC_KENBOX_2	0.1944
p.E729Q	DO471	BLCA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1944
p.E729Q	DO23720	LUAD	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1944
p.D739Y	TCGA-AA-A010	COAD	TCGA	GKENE	DEG_APCC_KENBOX_2	0.3056
p.K742N	TCGA-BP-4993	KIRC	TCGA	GKENE	DEG_APCC_KENBOX_2	0.3333
p.K742N	DO20171	KIRC	ICGC	GKENE	DEG_APCC_KENBOX_2	0.3333
p.E738K	TCGA-D3-A8GQ	SKCM	TCGA	GKENE	DEG_APCC_KENBOX_2	0.591
p.E738K	DO51246	SKCM	ICGC	GKENE	DEG_APCC_KENBOX_2	0.591
p.Q727E	DO14232	HNSC	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727E	DO231221	THCA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727E	SIDM01151	Hepatocellular Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727E	SIDM00807	Bladder Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727E	ACH-000483	Liver Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727E	ACH-001484	Leukemia	CCLE	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727E	SNU-182	liver	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727E	5637	urinary_tract	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	DO14232	HNSC	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	DO231221	THCA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	SIDM01151	Hepatocellular Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	SIDM00807	Bladder Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	ACH-000483	Liver Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	ACH-001484	Leukemia	CCLE	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	SNU-182	liver	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.Q727R	5637	urinary_tract	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.1389
p.D741G	DO231987	LICA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.25
p.G743E	DO220878	MELA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1944
p.G743E	DO222578	MELA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.1944
p.E731K	DO220877	MELA	ICGC	GKENE	DEG_APCC_KENBOX_2	0.25
p.E748Q	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.0556
p.E748Q	ACH-000861	Lung Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	0.0556
p.E748Q	HOP-62	lung	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.0556
p.G734R	SIDM01147	Gastric Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	0.6457
p.G734R	ACH-000427	Gastric Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	0.6457
p.G734R	NCI-N87	stomach	COSMIC	GKENE	DEG_APCC_KENBOX_2	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94985	Calsyntenin-1	DEG_APCC_KENBOX_2	896:900	GKENE	APC,CDC20,FZR1	0.6765	More...
Q9H2Y7	Zinc finger protein 106	DEG_APCC_KENBOX_2	883:887	GKENE	APC,CDC20,FZR1	0.9667	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	734:738	GKENE	APC,CDC20,FZR1	0.7023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENE

Degron related mutations and impact score

Drug responses associated with CNGB3 mutations

All proteins holding degron of GKENE